Immune cells act as the core components of a sophisticated and highly co-ordinated system designed to protect the body from pathogens, cancer and other external insults. However, in autoimmunity cells of the immune system is perturbed in such a way as to instead target normal healthy cells. The etiology of autoimmune diseases is multifactorial, with both genetic and environmental factors contributing.

Cytokine signaling plays a key regulatory function in immunity, impacting both immune cell development and function. Dysregulation of cytokine signaling has been implicated in a variety of immune disorders, including autoimmunity.

This Special Issue, entitled ‘Disrupted Cytokine Signaling Pathways in Autoimmunity’ will focus on the key role of perturbations in cytokine signaling in the etiology and pathophysiology of autoimmune diseases.

We cordially invite your quality submissions in this area, including both regular papers and review articles.

Keywords: Autoimmunity, inflammation, cytokine, receptor signaling, JAK, STAT, SOCS