Exploration of Endocrine and Metabolic Diseases

Exploration of Endocrine and Metabolic Diseases https://www.explorationpub.com/Journals/eemd Most Recent Articles : Exploration of Endocrine and Metabolic Diseases. en-us Tue, 12 May 2026 16:32:32 GMT Optimizing hormone replacement therapy for postmenopausal women with type 2 diabetes: a review https://www.explorationpub.com/Journals/eemd/Article/101430 Not applicable. Review Mon, 28 Apr 2025 00:00:00 GMT Mon, 28 Apr 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101430 Message of welcome from the editor-in-chief https://www.explorationpub.com/Journals/eemd/Article/10141 Not applicable. Editorial Thu, 16 Nov 2023 00:00:00 GMT Thu, 16 Nov 2023 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/10141 Application of chimeric antigen receptor-natural killer cells for the treatment of type 1 diabetes https://www.explorationpub.com/Journals/eemd/Article/10142 Not applicable. Review Fri, 17 Nov 2023 00:00:00 GMT Fri, 17 Nov 2023 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/10142 Recent advances in artificial intelligence-assisted endocrinology and diabetes https://www.explorationpub.com/Journals/eemd/Article/10144 Not applicable. Review Thu, 23 Nov 2023 00:00:00 GMT Thu, 23 Nov 2023 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/10144 Unique original endocrine findings: the endoplasmic reticulum-mitochondrial unit in steroid producing cells https://www.explorationpub.com/Journals/eemd/Article/10143 Not applicable. Commentary Tue, 21 Nov 2023 00:00:00 GMT Tue, 21 Nov 2023 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/10143 Development of adrenal 3-dimensional spheroid cultures: potential for the treatment of adrenal insufficiency and neurodegenerative diseases https://www.explorationpub.com/Journals/eemd/Article/10145 Not applicable. Original Article Tue, 28 Nov 2023 00:00:00 GMT Tue, 28 Nov 2023 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/10145 Metabolic syndrome in menopause https://www.explorationpub.com/Journals/eemd/Article/101440 Not applicable. Review Wed, 24 Sep 2025 00:00:00 GMT Wed, 24 Sep 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101440 Epigenetics in etiopathology of hyperprolactinemia https://www.explorationpub.com/Journals/eemd/Article/10146 Not applicable. Original Article Thu, 23 May 2024 00:00:00 GMT Thu, 23 May 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/10146 Diabetes and cancer: two epidemic diseases requiring an opposite therapeutic approach to target cells https://www.explorationpub.com/Journals/eemd/Article/10147 Not applicable. Perspective Thu, 23 May 2024 00:00:00 GMT Thu, 23 May 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/10147 Four hepatic steatosis indices in predicting quantitative computed tomography-based metabolic dysfunction-associated fatty liver disease https://www.explorationpub.com/Journals/eemd/Article/10148 Not applicable. Original Article Thu, 23 May 2024 00:00:00 GMT Thu, 23 May 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/10148 Hypoparathyroidism, deafness and renal dysplasia syndrome with bilateral cataract and bicornuate uterus caused by a de novo GATA3 mutation https://www.explorationpub.com/Journals/eemd/Article/10149 Not applicable. Case Report Mon, 27 May 2024 00:00:00 GMT Mon, 27 May 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/10149 Adult-onset testosterone deficiency: the usefulness of hormone replacement in reducing mortality in men with this common age-related condition https://www.explorationpub.com/Journals/eemd/Article/101410 Not applicable. Review Fri, 28 Jun 2024 00:00:00 GMT Fri, 28 Jun 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101410 Genome editing in the adrenal gland: a novel strategy for treating congenital adrenal hyperplasia https://www.explorationpub.com/Journals/eemd/Article/101411 Not applicable. Review Tue, 09 Jul 2024 00:00:00 GMT Tue, 09 Jul 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101411 Hypothetical involvement of stress hormones-induced reprograming of adult stem/progenitor cells in tumorigenesis https://www.explorationpub.com/Journals/eemd/Article/101412 Not applicable. Review Tue, 16 Jul 2024 00:00:00 GMT Tue, 16 Jul 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101412 The 2024 American Diabetes Association guidelines on Standards of Medical Care in Diabetes: key takeaways for laboratory https://www.explorationpub.com/Journals/eemd/Article/101413 Not applicable. Commentary Tue, 23 Jul 2024 00:00:00 GMT Tue, 23 Jul 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101413 Glycemic trends, app engagement and achievement of gestational diabetes guideline targets using a diabetes app and Bluetooth® connected blood glucose meters https://www.explorationpub.com/Journals/eemd/Article/101414 Not applicable. Original Article Wed, 24 Jul 2024 00:00:00 GMT Wed, 24 Jul 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101414 Testosterone undecanoate is associated with improved ageing male symptoms score in men with type 2 diabetes and adult-onset testosterone deficiency: re-analyzed results from a randomised controlled trial https://www.explorationpub.com/Journals/eemd/Article/101415 Not applicable. Original Article Tue, 13 Aug 2024 00:00:00 GMT Tue, 13 Aug 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101415 Endogenous glucocorticoids during skeletal ageing https://www.explorationpub.com/Journals/eemd/Article/101416 Not applicable. Review Fri, 16 Aug 2024 00:00:00 GMT Fri, 16 Aug 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101416 Beta thalassemia minor: a potential risk factor for osteopenia and osteoporosis https://www.explorationpub.com/Journals/eemd/Article/101417 Not applicable. Case Report Fri, 01 Nov 2024 00:00:00 GMT Fri, 01 Nov 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101417 Correction: A case series of three patients with extensive lung metastatic pheochromocytoma/paraganglioma: evaluation, treatment challenges, and outcomes https://www.explorationpub.com/Journals/eemd/Article/101420 Not applicable. Correction Fri, 20 Dec 2024 00:00:00 GMT Fri, 20 Dec 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101420 Patient diagnosed with acromegaly and pituitary apoplexy after breast carcinoma treatment: challenges in diagnosis and management https://www.explorationpub.com/Journals/eemd/Article/101419 Not applicable. Case Report Wed, 27 Nov 2024 00:00:00 GMT Wed, 27 Nov 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101419 Waist-to-height ratio as a novel marker of metabolic syndrome in patients with type 2 diabetes mellitus https://www.explorationpub.com/Journals/eemd/Article/101421 Not applicable. Original Article Fri, 10 Jan 2025 00:00:00 GMT Fri, 10 Jan 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101421 A brief approach to hypertension in type 2 diabetes mellitus https://www.explorationpub.com/Journals/eemd/Article/101422 Not applicable. Review Wed, 05 Feb 2025 00:00:00 GMT Wed, 05 Feb 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101422 Whole-exome sequencing uncovered the 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as the cause of lethal in a Vietnamese infant https://www.explorationpub.com/Journals/eemd/Article/101423 Not applicable. Case Report Fri, 14 Feb 2025 00:00:00 GMT Fri, 14 Feb 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101423 A case series of three patients with extensive lung metastatic pheochromocytoma/paraganglioma: evaluation, treatment challenges, and outcomes https://www.explorationpub.com/Journals/eemd/Article/101418 Not applicable. Case Report Fri, 15 Nov 2024 00:00:00 GMT Fri, 15 Nov 2024 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101418 Healthy adipose tissue after menopause: contribution of balanced diet and physical exercise https://www.explorationpub.com/Journals/eemd/Article/101424 Not applicable. Review Fri, 14 Mar 2025 00:00:00 GMT Fri, 14 Mar 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101424 Significance of FXR agonists in MASLD treatment: a deep dive into lipid alteration by analytical techniques https://www.explorationpub.com/Journals/eemd/Article/101425 Not applicable. Review Wed, 26 Mar 2025 00:00:00 GMT Wed, 26 Mar 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101425 Glucocorticoid receptor alpha: origins and functions of the master regulator of homeostatic corrections in health and critical illness https://www.explorationpub.com/Journals/eemd/Article/101426 Not applicable. Review Fri, 28 Mar 2025 00:00:00 GMT Fri, 28 Mar 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101426 Circulating endocannabinoids and brain anatomy: unraveling the weight loss connection through lifestyle and surgery approaches https://www.explorationpub.com/Journals/eemd/Article/101427 Not applicable. Review Tue, 08 Apr 2025 00:00:00 GMT Tue, 08 Apr 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101427 Updates from the 2025 American Diabetes Association guidelines on standards of medical care in diabetes https://www.explorationpub.com/Journals/eemd/Article/101428 Not applicable. Commentary Tue, 15 Apr 2025 00:00:00 GMT Tue, 15 Apr 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101428 Double heterozygous pathogenic variants in BRCA2 and CHEK2 in a girl with adrenocortical carcinoma https://www.explorationpub.com/Journals/eemd/Article/101429 Not applicable. Case Report Thu, 17 Apr 2025 00:00:00 GMT Thu, 17 Apr 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101429 Intravenous calcitriol: a critical intervention for severe postoperative hypoparathyroidism when oral administration is not feasible https://www.explorationpub.com/Journals/eemd/Article/101431 Not applicable. Case Report Fri, 09 May 2025 00:00:00 GMT Fri, 09 May 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101431 Synergistic glucocorticoids, vitamins, and microbiome strategies for gut protection in critical illness https://www.explorationpub.com/Journals/eemd/Article/101432 Not applicable. Review Thu, 15 May 2025 00:00:00 GMT Thu, 15 May 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101432 Comparative pharmacodynamic analysis of resmetirom, semaglutide and obeticholic acid in translational mouse models of MASH https://www.explorationpub.com/Journals/eemd/Article/101433 Not applicable. Original Article Tue, 24 Jun 2025 00:00:00 GMT Tue, 24 Jun 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101433 Hormone oscillations in the HPA axis: dynamical diseases and beyond https://www.explorationpub.com/Journals/eemd/Article/101434 Not applicable. Original Article Tue, 24 Jun 2025 00:00:00 GMT Tue, 24 Jun 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101434 A comprehensive review on diabetes mellitus and heart failure https://www.explorationpub.com/Journals/eemd/Article/101435 Not applicable. Mini Review Tue, 01 Jul 2025 00:00:00 GMT Tue, 01 Jul 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101435 Prevalence and incidence of co-morbid lung disease associated with type 2 diabetes from the UK Biobank https://www.explorationpub.com/Journals/eemd/Article/101436 Not applicable. Original Article Fri, 04 Jul 2025 00:00:00 GMT Fri, 04 Jul 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101436 Glucocorticoid signalling coordinating circadian rhythms between the glymphatic system and sleep contributes to brain health https://www.explorationpub.com/Journals/eemd/Article/101437 Not applicable. Review Wed, 16 Jul 2025 00:00:00 GMT Wed, 16 Jul 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101437 Bidirectional relationship between vitamin D deficiency and type 1/type 2 diabetes mellitus: a systematic review and meta-analysis https://www.explorationpub.com/Journals/eemd/Article/101438 Not applicable. Meta-Analysis Fri, 18 Jul 2025 00:00:00 GMT Fri, 18 Jul 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101438 Taste genomics and type 2 diabetes mellitus: a systematic qualitative meta-synthesis https://www.explorationpub.com/Journals/eemd/Article/101439 Not applicable. Systematic Review Fri, 08 Aug 2025 00:00:00 GMT Fri, 08 Aug 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101439 Diabetes mellitus and hepatosteatosis: a narrative review https://www.explorationpub.com/Journals/eemd/Article/101446 Not applicable. Review Mon, 10 Nov 2025 00:00:00 GMT Mon, 10 Nov 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101446 Baicalin and ginsenoside Rb1 regulate the expression of adipocyte GRK2 and browning markers under lipid overload https://www.explorationpub.com/Journals/eemd/Article/101441 Not applicable. Original Article Mon, 13 Oct 2025 00:00:00 GMT Mon, 13 Oct 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101441 Gestational diabetes mellitus in India: metabolic burden, clinical gaps, and therapeutic opportunities—a systematic review https://www.explorationpub.com/Journals/eemd/Article/101442 Not applicable. Systematic Review Fri, 17 Oct 2025 00:00:00 GMT Fri, 17 Oct 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101442 Clinical management strategies for type 2 diabetes mellitus with metabolic dysfunction-associated fatty liver disease: an umbrella review of systematic reviews and meta-analyses https://www.explorationpub.com/Journals/eemd/Article/101443 Not applicable. Systematic Review Thu, 23 Oct 2025 00:00:00 GMT Thu, 23 Oct 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101443 Disruption of the transsulfuration pathway as a sulfur-driven etiology of insulin resistance: proinsulin misfolding, disulfide bond deformation, and PDI dysregulation https://www.explorationpub.com/Journals/eemd/Article/101444 Not applicable. Review Mon, 03 Nov 2025 00:00:00 GMT Mon, 03 Nov 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101444 Pharmacological inhibition of type 5 adenylyl cyclase, a model for healthful aging, enhanced exercise capacity and glucose tolerance https://www.explorationpub.com/Journals/eemd/Article/101445 Not applicable. Short Communication Thu, 06 Nov 2025 00:00:00 GMT Thu, 06 Nov 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101445 Hormonal changes during aging and their effects on quality of life https://www.explorationpub.com/Journals/eemd/Article/101447 Not applicable. Review Mon, 10 Nov 2025 00:00:00 GMT Mon, 10 Nov 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101447 Modeling the progression of NAFLD: a multi-state Markov approach based on BMI classification in the Chinese population https://www.explorationpub.com/Journals/eemd/Article/101448 Not applicable. Original Article Thu, 13 Nov 2025 00:00:00 GMT Thu, 13 Nov 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101448 The pharma race to develop increasingly more potent incretin-based therapeutics—what is for the clinicians to know https://www.explorationpub.com/Journals/eemd/Article/101449 Not applicable. Commentary Fri, 14 Nov 2025 00:00:00 GMT Fri, 14 Nov 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101449 Psychotropic medications and metabolic side effects https://www.explorationpub.com/Journals/eemd/Article/101450 Not applicable. Review Mon, 24 Nov 2025 00:00:00 GMT Mon, 24 Nov 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101450 Glucocorticoid receptor alpha as a core survival receptor: mechanisms, and implications for health and critical illness https://www.explorationpub.com/Journals/eemd/Article/101451 Not applicable. Review Mon, 01 Dec 2025 00:00:00 GMT Mon, 01 Dec 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101451 Effects of GLP-1 receptor agonists and dual incretin agonists on adipocyte type and size https://www.explorationpub.com/Journals/eemd/Article/101452 Not applicable. Review Fri, 19 Dec 2025 00:00:00 GMT Fri, 19 Dec 2025 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101452 A novel therapeutic strategy of obesity from the perspective of SPMs https://www.explorationpub.com/Journals/eemd/Article/101453 Not applicable. Review Mon, 05 Jan 2026 00:00:00 GMT Mon, 05 Jan 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101453 Cardiovascular effects of endocrine hypertension: insights from primary aldosteronism, pheochromocytoma, and Cushing syndrome https://www.explorationpub.com/Journals/eemd/Article/101454 Not applicable. Review Thu, 08 Jan 2026 00:00:00 GMT Thu, 08 Jan 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101454 Osteoporosis: definition, diagnosis, and considerations prior to starting treatment https://www.explorationpub.com/Journals/eemd/Article/101456 Not applicable. Review Fri, 09 Jan 2026 00:00:00 GMT Fri, 09 Jan 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101456 Association between APOA1 gene (rs670) single-nucleotide polymorphism and dyslipidaemia: a systematic review and meta-analysis https://www.explorationpub.com/Journals/eemd/Article/101455 Not applicable. Meta-Analysis Fri, 09 Jan 2026 00:00:00 GMT Fri, 09 Jan 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101455 Impaired cytokines in diabetes and diabetic foot ulcers: mechanisms and prospects https://www.explorationpub.com/Journals/eemd/Article/101457 Not applicable. Review Wed, 21 Jan 2026 00:00:00 GMT Wed, 21 Jan 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101457 Treating obesity with GLP-1 RAs: does sex matter? A commentary on the meta-analysis by Yang et al. (J Diabetes 2025;17(3):e70063) https://www.explorationpub.com/Journals/eemd/Article/101458 Not applicable. Commentary Mon, 02 Feb 2026 00:00:00 GMT Mon, 02 Feb 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101458 Normal triglyceride levels are positively associated with plasma glucose levels and type 2 diabetes diagnosis in Chinese adults https://www.explorationpub.com/Journals/eemd/Article/101459 Not applicable. Original Article Thu, 12 Feb 2026 00:00:00 GMT Thu, 12 Feb 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101459 Progesterone for reproductive vitality and women’s healthy ageing https://www.explorationpub.com/Journals/eemd/Article/101460 Not applicable. Review Thu, 26 Feb 2026 00:00:00 GMT Thu, 26 Feb 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101460 Innovative regenerative genetic and nano therapies for diabetes and metabolic disease https://www.explorationpub.com/Journals/eemd/Article/101461 Not applicable. Review Mon, 09 Mar 2026 00:00:00 GMT Mon, 09 Mar 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101461 Fat deposits and their relationship with type 2 diabetes in patients with metabolic syndrome https://www.explorationpub.com/Journals/eemd/Article/101462 Not applicable. Original Article Tue, 10 Mar 2026 00:00:00 GMT Tue, 10 Mar 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101462 Development and validation of a novel risk assessment model for necrotizing fasciitis in patients with diabetic foot https://www.explorationpub.com/Journals/eemd/Article/101463 Not applicable. Original Article Thu, 12 Mar 2026 00:00:00 GMT Thu, 12 Mar 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101463 Obesity and antibiotic exposure: an overhyped theory https://www.explorationpub.com/Journals/eemd/Article/101464 Not applicable. Review Thu, 19 Mar 2026 00:00:00 GMT Thu, 19 Mar 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101464 Epiploic appendagitis during rapid weight loss associated with tirzepatide therapy: a case report https://www.explorationpub.com/Journals/eemd/Article/101465 Not applicable. Case Report Thu, 02 Apr 2026 00:00:00 GMT Thu, 02 Apr 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101465 Osteoarthritis from a female perspective https://www.explorationpub.com/Journals/eemd/Article/101466 Not applicable. Review Fri, 10 Apr 2026 00:00:00 GMT Fri, 10 Apr 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101466 Circadian rhythm modulation in metabolic disease: targeting clock genes for obesity and insulin resistance https://www.explorationpub.com/Journals/eemd/Article/101467 Not applicable. Review Thu, 16 Apr 2026 00:00:00 GMT Thu, 16 Apr 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101467 Effects of sugar and confectionery consumption on serum testosterone levels in males: a narrative review https://www.explorationpub.com/Journals/eemd/Article/101468 Not applicable. Review Thu, 23 Apr 2026 00:00:00 GMT Thu, 23 Apr 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101468 Effects of high-intensity interval training and concurrent training on body composition and metabolic profile in postmenopausal women with overweight or obesity: a clinical trial https://www.explorationpub.com/Journals/eemd/Article/101469 Not applicable. Original Article Thu, 30 Apr 2026 00:00:00 GMT Thu, 30 Apr 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101469 The role of the resveratrol-sirtuin axis in the treatment of metabolic dysfunction-associated diseases https://www.explorationpub.com/Journals/eemd/Article/101470 Not applicable. Review Wed, 06 May 2026 00:00:00 GMT Wed, 06 May 2026 00:00:00 GMT https://www.explorationpub.com/Journals/eemd/Article/101470