Exploration of Immunology

From: Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases

Table 2. Registered clinical trials of MSCs in GvHD and HSCT. In this table a number of representable clinical trials are summarized Data were considered as defined in the www.clinicaltrials.gov. Intravenous infusion of MSCs was performed in the listed clinical trials

NCT number	Title	Status	Phase	No of Patients	MSCs Origin	No of MSCs
NCT01956903	Treatment of Refractory Acute Graft-Versus-Host Disease by Sequential Infusion of Allogenic Mesenchymal Stem Cell	Completed	I/II	15	Allogeneic-MSCs	0.7 × 10⁶ cells/kg – 2.8 × 10⁶ cells/kg
NCT01222039	Multicenter Clinical Trial for the Evaluation of Mesenchymal Stem Cells from Adipose Tissue in Patients With Chronic Graft Versus Host Disease	Completed	I/II	19	Allogeneic-MSCs	1 × 10⁶ cells/kg – 3 × 10⁶ cells/kg
NCT00366145	Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease	Completed	III	260	Undefined	2 × 10⁶ cells/kg
NCT04692376	MSC for Treatment of cGVHD After Allo-HSCT	Recruiting	II	152	Undefined	1 × 10⁶ cells/kg
NCT02824653	Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients with Steroid-refractory GVHD	Completed	I/II	10	Allogeneic-BM-MSCs	Undefined
NCT03106662	Mesenchymal Stem Cell Infusion in Haploidentical Hematopoietic Stem Cell Transplantation in Patients with Hematological Malignancies	Completed	III	6	Undefined	2.8 × 10⁶ cells/kg
NCT04247945	Co-transplantation of MSC in the Setting of Allo-HSCT	Recruiting	II/III	120	Undefined	Undefined
NCT00823316	Safety and Efficacy Study of Umbilical Cord Blood-Drived Mesenchymal Stem Cells to Promote Engraftment of Unrelated Hematopoietic Stem Cell Transplantation	Completed	I/II	10	UCB-MSCs	5 doses of 1 × 10⁶ cells/kg
NCT04692376	MSC for Treatment of cGVHD After Allo-HSCT	Recruiting	II	152	Undefined	8 doses of 8 × 10⁶ cells/kg
NCT00136903	Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease	Completed	II	33	Allogeneic	2 × 10⁶ cells/kg

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PM wrote the initial draft of the manuscript. EM and TC revised the manuscript. CSG made the final approval for the manuscript.

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