Registered clinical trials of MSCs in GvHD and HSCT. In this table a number of representable clinical trials are summarized Data were considered as defined in the www.clinicaltrials.gov. Intravenous infusion of MSCs was performed in the listed clinical trials
| NCT number | Title | Status | Phase | No of Patients | MSCs Origin | No of MSCs |
|---|---|---|---|---|---|---|
| NCT01956903 | Treatment of Refractory Acute Graft-Versus-Host Disease by Sequential Infusion of Allogenic Mesenchymal Stem Cell | Completed | I/II | 15 | Allogeneic-MSCs | 0.7 × 106 cells/kg – 2.8 × 106 cells/kg |
| NCT01222039 | Multicenter Clinical Trial for the Evaluation of Mesenchymal Stem Cells from Adipose Tissue in Patients With Chronic Graft Versus Host Disease | Completed | I/II | 19 | Allogeneic-MSCs | 1 × 106 cells/kg – 3 × 106 cells/kg |
| NCT00366145 | Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease | Completed | III | 260 | Undefined | 2 × 106 cells/kg |
| NCT04692376 | MSC for Treatment of cGVHD After Allo-HSCT | Recruiting | II | 152 | Undefined | 1 × 106 cells/kg |
| NCT02824653 | Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients with Steroid-refractory GVHD | Completed | I/II | 10 | Allogeneic-BM-MSCs | Undefined |
| NCT03106662 | Mesenchymal Stem Cell Infusion in Haploidentical Hematopoietic Stem Cell Transplantation in Patients with Hematological Malignancies | Completed | III | 6 | Undefined | 2.8 × 106 cells/kg |
| NCT04247945 | Co-transplantation of MSC in the Setting of Allo-HSCT | Recruiting | II/III | 120 | Undefined | Undefined |
| NCT00823316 | Safety and Efficacy Study of Umbilical Cord Blood-Drived Mesenchymal Stem Cells to Promote Engraftment of Unrelated Hematopoietic Stem Cell Transplantation | Completed | I/II | 10 | UCB-MSCs | 5 doses of 1 × 106 cells/kg |
| NCT04692376 | MSC for Treatment of cGVHD After Allo-HSCT | Recruiting | II | 152 | Undefined | 8 doses of 8 × 106 cells/kg |
| NCT00136903 | Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease | Completed | II | 33 | Allogeneic | 2 × 106 cells/kg |