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Neoantigen-based immunotherapy: advancing precision medicine in cancer and glioblastoma treatment through discovery and innovation
Neoantigen-based immunotherapy has emerged as a transformative approach in cancer treatment, offering precision medicine strategies that target tumor-specific antigens derived from genetic, transcri
Published: April 27, 2025 Explor Target Antitumor Ther. 2025;6:1002313
Open Access
Review
Cytokine-based immunotherapy for gastric cancer: targeting inflammation for tumor control
Emerging cancer immunotherapy methods, notably cytokine-based ones that modify immune systems’ inflammatory reactions to tumor cells, may help slow gastric cancer progression. Cytokines, tiny sign
Published: April 26, 2025 Explor Target Antitumor Ther. 2025;6:1002312
Open Access
Review
Viral infections and immune modulation in bladder cancer: implications for immunotherapy
This review explores the intricate relationship between viral infections and Bacillus Calmette-Guerin (BCG) efficacy, emphasizing immune modulation mechanisms that may influence treatment outcomes.
Published: April 24, 2025 Explor Target Antitumor Ther. 2025;6:1002311
Open Access
Review
Modulation of anti-tumour immunity by XPO1 inhibitors
Exportin-1 (XPO1) is a nuclear export protein that, when overexpressed, can facilitate cancer cell proliferation and survival and is frequently overexpressed or mutated in cancer patients. As such,
Published: April 23, 2025 Explor Target Antitumor Ther. 2025;6:1002310
Open Access
Case Report
Eosinophil cytolysis with or without ETosis in four cases of human gastric cancer: a comparative ultrastructural study
The ultrastructural morphology of eosinophil cytolysis and extracellular trap cell death (ETosis) has predominantly been examined in non-neoplastic eosinophil-associated diseases, with a limited inv
Published: April 21, 2025 Explor Target Antitumor Ther. 2025;6:1002309
Open Access
Review
Nanoimmunotherapy: the smart trooper for cancer therapy
Immunotherapy has gathered significant attention and is now a widely used cancer treatment that uses the body’s immune system to fight cancer. Despite initial successes, its broader clinical appli
Published: April 10, 2025 Explor Target Antitumor Ther. 2025;6:1002308
Open Access
Review
Current strategies for the design of PROTAC linkers: a critical review
PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an “anchor” to bind to an E3 ubiquitin ligase and a “warhead”
Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:273–312
Open Access
Review
The impact of tumour pH on cancer progression: strategies for clinical intervention
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasi
Published: April 28, 2020 Explor Target Antitumor Ther. 2020;1:71–100
Open Access
Review
Inhibitors of the Fanconi anaemia pathway as potential antitumour agents for ovarian cancer
The Fanconi anaemia (FA) pathway is an important mechanism for cellular DNA damage repair, which functions to remove toxic DNA interstrand crosslinks. This is particularly relevant in the context of
Published: February 29, 2020 Explor Target Antitumor Ther. 2020;1:26–52
Open Access
Review
Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors
Chronic lymphocytic leukemia is a common form of leukemia and is dependent on growth-promoting signaling via the B-cell receptor. The Bruton tyrosine kinase (BTK) is an important mediator of B-cell
Published: June 29, 2020 Explor Target Antitumor Ther. 2020;1:131–152
Open Access
Review
Novel approaches for the rational design of PROTAC linkers
Proteolysis targeting chimeras (PROTACs) represent a promising class of hetero-bivalent molecules that facilitate ubiquitination of a target protein by simultaneously binding and bringing together b
Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:381–390
Open Access
Review
Early-stage triple negative breast cancer: the therapeutic role of immunotherapy and the prognostic value of pathological complete response
Triple negative breast cancer (TNBC) represents an aggressive disease associated with a high risk of recurrence after curative treatment and a poor prognosis in the metastatic setting. Chemotherapy
Published: February 28, 2024 Explor Target Antitumor Ther. 2024;5:232–250
Open Access
Review
Current strategies for the design of PROTAC linkers: a critical review
PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an “anchor” to bind to an E3 ubiquitin ligase and a “warhead”
Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:273–312
Open Access
Perspective
Encouraging probiotics for the prevention and treatment of immune-related adverse events in novel immunotherapies against malignant glioma
Among the malignant tumors in the central nervous system (CNS), glioma is the most challenging tumor to the public society, which accounts for the majority of intracranial malignant tumors with impa
Published: December 27, 2022 Explor Target Antitumor Ther. 2022;3:817–827
Open Access
Perspective
Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies
Immunotherapy strategies targeting immune checkpoint molecules such as programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) are revolutionizing oncology. However,
Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:460–473
Open Access
Perspective
Potential tactics with certain gut microbiota for the treatment of unresectable hepatocellular carcinoma
Hepatocellular carcinoma (HCC) constitutes an extremely malignant form of primary liver cancer. Intricate connections linking to the immune system might be associated with the pathogenesis of HCC. M
Published: August 24, 2023 Explor Target Antitumor Ther. 2023;4:556–568
Open Access
Review
The impact of tumour pH on cancer progression: strategies for clinical intervention
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasi
Published: April 28, 2020 Explor Target Antitumor Ther. 2020;1:71–100
Open Access
Review
Novel approaches for the rational design of PROTAC linkers
Proteolysis targeting chimeras (PROTACs) represent a promising class of hetero-bivalent molecules that facilitate ubiquitination of a target protein by simultaneously binding and bringing together b
Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:381–390
Open Access
Review
Current strategies for the design of PROTAC linkers: a critical review
PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an “anchor” to bind to an E3 ubiquitin ligase and a “warhead”
Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:273–312
Open Access
Review
The impact of tumour pH on cancer progression: strategies for clinical intervention
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasi
Published: April 28, 2020 Explor Target Antitumor Ther. 2020;1:71–100
Open Access
Review
Novel approaches for the rational design of PROTAC linkers
Proteolysis targeting chimeras (PROTACs) represent a promising class of hetero-bivalent molecules that facilitate ubiquitination of a target protein by simultaneously binding and bringing together b
Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:381–390
Open Access
Review
Diagnostic value of liquid biopsy in the era of precision medicine: 10 years of clinical evidence in cancer
Liquid biopsy is a diagnostic repeatable test, which in last years has emerged as a powerful tool for profiling cancer genomes in real-time with minimal invasiveness and tailoring oncological decisi
Published: February 28, 2023 Explor Target Antitumor Ther 2023;4:102–138
Open Access
Review
The clinical advances of proteolysis targeting chimeras in oncology
Proteolysis targeting chimeras (PROTACs) are a class of small molecules designed to target proteins for degradation. Their novel and unique modes of action provide PROTACs with the potential for the
Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:511–521
Open Access
Review
Potential role of resveratrol and its nano-formulation as anti-cancer agent
The uncontrolled and metastatic nature of cancer makes it worse and more unpredictable. Hence, many therapy and medication are used to control and treat cancer. However, apart from this, many medica
Published: October 31, 2022 Explor Target Antitumor Ther. 2022;3:643–658
Special Issues
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Artificial Intelligence Technology in Tumor Radiotherapy
Prof. Tuan D. Pham
September 30, 2025
Published Articles: 0
Liquid Biopsy: Has Already Changed the Clinical Decision-Making in Solid Tumors Treatment?
Dr. Giulia Martini
June 30, 2025
Published Articles: 0
Predictive and Prognostic Biomarkers in Cancer: Towards the Precision Medicine Era
Prof. Luca Falzone Dr. Antonio Rizzo Dr. Stefano Marletta Dr. Graziana Spoto
February 28, 2025
Published Articles: 2
Potential Clinical Applications of Inorganic Nanomaterials in Cancer
Prof. Javier Reguera
April 30, 2025
Published Articles: 1
Potential of Non-Coding RNAs in Cancer Research and Treatment
Prof. Francesco Bertoni Dr. Luciano Cascione
June 30, 2025
Published Articles: 0
Novel Biomarkers in the Immunotherapy Era
Dr. Carminia Maria Della Corte Dr. Floriana Morgillo Dr. Caterina De Rosa
December 31, 2024
Published Articles: 1
Comprehensive Immunotherapy of Solid Tumors
Dr. Michela Valeria Rita Starace
October 31, 2024
Published Articles: 4
Advances in Cancer Genomics and Therapeutic Targets
Prof. Apostolos Zaravinos
October 31, 2024
Published Articles: 2
Molecular Mechanisms and Intervention Options in Metastatic Spread of Cancer
Dr. Katrin Sak
June 30, 2025
Published Articles: 2
Immunotherapy Strategies for Non-small Cell Lung Cancer
Prof. Stergios Boussios Prof. Matin Sheriff
July 31, 2024
Published Articles: 5
Use of Different Radiation Treatment Modalities in Cancer Therapy: The Role of Inflammation and Immune Response
Prof. Alexandros Georgakilas
May 31, 2025
Published Articles: 1
Immune Checkpoint Therapy and Biomarkers in Cancer
Prof. Eyad Elkord
December 31, 2024
Published Articles: 7
Mechanisms of Targeted Therapy Resistance and Reversal Strategies
Prof. Pier Paolo Piccaluga
December 31, 2024
Published Articles: 3
Current Innovative Cancer Treatment
Prof. Salem Chouaib Dr. Ghazi Jerbi
February 29, 2024
Published Articles: 0
Cancer Epigenetics: Implications for Novel Therapeutic Strategies
Prof. Mingzhou Guo
February 01, 2025
Published Articles: 2
Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
Prof. Hailin Tang
October 31, 2023
Published Articles: 4
Molecular Diagnosis and Personalized Therapy of Cancer
Prof. Monica Fedele Prof. Andrea Vecchione
May 31, 2024
Published Articles: 4
Innovative Strategies to Target Triple-negative Breast Cancer
Dr. Laura Cerchia Dr. Simona Camorani
May 31, 2023
Published Articles: 8
Posttranslational Modifications in Health and Disease
Prof. Oliver Krämer
December 31, 2024
Published Articles: 4
The Role of Bcl-2 Family Proteins in Cancer Progression and Their Relevance to Cancer Therapy
Dr. Donatella Del Bufalo Dr. Germain Gillet
November 30, 2021
Published Articles: 5
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