Exploration of Immunology

From: Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases

Table 4. Registered clinical trials of MSCs in COVID-19. In this table, a number of representable clinical trials are summarized. Data were considered as defined in the www.clinicaltrials.gov. Intravenous infusion of MSCs was performed in the listed clinical trials

NCT number	Title	Status	Phase	No of patients	MSCs origin	No of MSCs
NCT04444271	Mesenchymal Stem Cell Infusion for COVID-19 Infection	Recruiting	II	10	Frozen MSCs	2 × 10⁶ cells/kg
NCT04713878	Mesenchymal Stem Cells Therapy in Patients With COVID-19 Pneumonia	Completed	N/A	21	Undefined	Undefined
NCT04565665	Cord Blood-Derived Mesenchymal Stem Cells for the Treatment of COVID-19 Related Acute Respiratory Distress Syndrome	Recruiting	I	70	UCB-MSCs	Undefined
NCT04416139	Mesenchymal Stem Cell for Acute Respiratory Distress Syndrome Due for COVID-19	Recruiting	II	10	Allogeneic-MSCs	1 × 10⁶ cells/kg
NCT04252118	Mesenchymal Stem Cell Treatment for Pneumonia Patients Infected With COVID-19	Recruiting	I	20	Undefined	3 times of 3 × 10⁷ cells
NCT04313322	Treatment of COVID-19 Patients Using Wharton’s Jelly-Mesenchymal Stem Cells	Recruiting	I	5	WJ-MSCs	Undefined
NCT04336254	Safety and Efficacy Study of Allogeneic Human Dental Pulp Mesenchymal Stem Cells to Treat Severe COVID-19 Patients	Recruiting	I/II	20	Allogeneic Dental Pulp MSCs	3 × 10⁷ cells
NCT04611256	Mesenchymal Stem Cells in Patients Diagnosed With COVID-19	Recruiting	I	20	AT-MSCs	1 × 10⁶ cells/kg
NCT04346368	Bone Marrow-Derived Mesenchymal Stem Cell Treatment for Severe Patients With Coronavirus Disease-19 (COVID-19)	Not Yet Recruiting	I/II	20	BM-MSCs	1 × 10⁶ cells/kg
NCT04366271	Clinical Trial of Allogeneic Mesenchymal Cells From Umbilical Cord Tissue in Patients With COVID-19	Recruiting	II	106	Allogeneic UC-MSCs	Undefined

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PM wrote the initial draft of the manuscript. EM and TC revised the manuscript. CSG made the final approval for the manuscript.

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