Summary of the comparison between ISTH and CLSI guidelines for LA detection
| Category | ISTH 2020 | CLSI 2014 |
|---|---|---|
| Sample preparation | Double centrifugation | Double centrifugation |
| Assay to use | dRVVT and APTT | dRVVT and APTT and/or others |
| Testing order | Screening => mixing & confirmatory | Screening => confirmatory => mixing |
| Calculations for PL-dependence | Normalized ratio or percentage correction | Normalized ratio or percentage correction |
| Mixing test | Perform on: mixture with NPP Interpret with MTC | Perform on: mixture with NPP Interpret with MTC or ICA |
MTC: mixing test-specific cut-off; ICA: index of circulating anticoagulant