Relationship between aPLs and recurrent thrombosis in patients with PAPS
| aPL | Recurrent thrombosis | P | OR (95% CI) | ||
|---|---|---|---|---|---|
| Yes, n (%) | No, n (%) | ||||
| IgG aCL, n = 52; ELISA | + | 31 (91) | 9 (50) | 0.002 | 10.33 (2.20–48.37) |
| – | 3 (9) | 9 (50) | |||
| IgM aCL, n = 52; ELISA | + | 7 (21) | 4 (22) | 0.89 | 0.90 (0.21–3.76) |
| – | 27 (79) | 14 (78) | |||
| IgG anti-β2-GPI, n = 52; ELISA | + | 29 (85) | 9 (50) | 0.004 | 7.50 (1.79–31.36) |
| – | 4 (15) | 9 (50) | |||
| IgM anti-β2-GPI, n = 52; ELISA | + | 8 (23) | 4 (22) | 0.91 | 1.07 (0.26–4.36) |
| – | 26 (77) | 14 (78) | |||
| IgG aPS/PT, n = 52; ELISA | + | 29 (85) | 8 (44) | 0.003 | 7.25 (1.85–28.35) |
| – | 5 (15) | 10 (56) | |||
| IgM aPS/PT, n = 52; ELISA | + | 13 (38) | 7 (39) | 0.96 | 0.97 (0.29–3.23) |
| – | 21 (62) | 11 (61) | |||
| aCL with anti-β2-GPI, n = 52; ELISA | + | 29 (85) | 9 (50) | 0.009 | 5.79 (1.48–22.58) |
| – | 5 (15) | 9 (50) | |||
| IgG aCL with IgG anti-β2-GPI and with IgG aPS/PT, n = 52; ELISA | + | 27 (79) | 7 (39) | 0.005 | 6.06 (1.66–22.09) |
| – | 7 (21) | 11 (61) | |||
| IgG aCL, n = 52; CLA | + | 33 (97) | 11 (61) | 0.007 | 21.00 (2.17–202.78) |
| – | 1 (3) | 7 (39) | |||
| IgM aCL, n = 52; CLA | + | 13 (38) | 6 (33) | 0.72 | 1.23 (0.36–4.23) |
| – | 21 (62) | 12 (67) | |||
| IgA aCL, n = 49; CLA | + | 21 (66) | 5 (29) | 0.01 | 4.58 (1.23–16.94) |
| – | 11 (34) | 12 (71) | |||
| IgG anti-β2-GPI, n = 52; CLA | + | 33 (97) | 9 (50) | 0.002 | 32.00 (3.33–307.02) |
| – | 1 (3) | 9 (50) | |||
| IgM anti-β2-GPI, n = 52; CLA | + | 13 (38) | 6 (33) | 0.72 | 1.23 (0.36–4.23) |
| – | 21 (62) | 12 (67) | |||
| IgA anti-β2-GPI, n = 49; CLA | + | 18 (37) | 5 (29) | 0.07 | 3.08 (0.84–11.20) |
| – | 14 (63) | 12 (71) | |||
| IgG anti-β2-GPIDI, n = 48; CLA | + | 29 (93) | 8 (47) | 0.001 | 16.31 (2.77–96.03) |
| – | 2 (7) | 9 (53) | |||
| aCL with anti-β2-GPI, n = 52; CLA | + | 32 (94) | 11 (61) | 0.008 | 10.18 (1.74–59.24) |
| – | 2 (6) | 7 (39) | |||
| IgG aCL with IgG anti-β2-GPI and with IgG anti-β2-GPIDI, n = 48; CLA | + | 29 (93) | 7 (41) | 0.0006 | 20.71 (3.48–123.00) |
| – | 2 (7) | 10 (59) | |||
+: positive aPLs; –: negative aPLs. P: reliability. P value ≤ 0.05 represents significance difference