Pro-angiogenic role of C1q in various contexts
| Angiogenic role of C1q in: | Key finding(s) | Model(s) | Reference |
|---|---|---|---|
| Pregnancy | C1q acts as a molecular bridge between DECs and invading trophoblast, triggering the activation of ERK1/MAPK signaling cascade | In vitro assays (human): DECs, trophoblasts | [14] |
| Wound healing | C1q is expressed at the wound site and has a pro-angiogenic effect similar to VEGF; involvement of gC1qR | In vitro assays (human): HUVECs Ex vivo assays (rat): aortic ring assay | [13] |
| Post-stroke | C1q stimulates the formation of new capillaries, having a pro-angiogenic effect; involvement of LIAR1 | In vivo assays (rat): pMCAO rat model In vitro assays (human and rat): RBMECs and HBMECs | [91] |
| Cancer | C1q stimulates angiogenesis in some types of tumors | In vivo assays (mouse): C1qa–/– mouse | [92] |
HUVECs: human umbilical vein ECs; pMCAO: permanent middle cerebral artery occlusion; RBMECs: rat brain microvascular ECs; HBMECs: human brain microvascular ECs; LIAR1: leukocyte-associated Ig-like receptor 1