Exploration of Immunology

Subtype of DC	Surface markers
cDC	CD1c, CD11c, CD33
mDC	CD163, CD64, CD14, CD11b
iDC	CD14, CD83
fDC	CD21, CD35
pDC	CD123, CD303, CD304, FasL
LHC	CD1a, langerin (CD207)
imDC	CD1c, CD303

Declarations

Author contributions

HP: Writing—original draft, Writing—review & editing.

Conflicts of interest

The author declares that he has no conflicts of interest.

Ethical approval

According to the local Ethics Committee, all figures in this article are fully anonymized, so an ethical approval is not needed.

Consent to participate

All figures in this article are fully anonymized, so consent to participate is not needed.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

References

Chu T, Jaffe R. The normal Langerhans cell and the LCH cell. Br J Cancer Suppl. 1994;23:S4–10. [PubMed] [PMC]

Todate A, Chida K, Suda T, Imokawa S, Sato J, Ide K, et al. Increased numbers of dendritic cells in the bronchiolar tissues of diffuse panbronchiolitis. Am J Respir Crit Care Med. 2000;162:148–53. [DOI] [PubMed]

Demedts IK, Brusselle GG, Vermaelen KY, Pauwels RA. Identification and characterization of human pulmonary dendritic cells. Am J Respir Cell Mol Biol. 2005;32:177–84. [DOI] [PubMed]

Dutertre CA, Becht E, Irac SE, Khalilnezhad A, Narang V, Khalilnezhad S, et al. Single-cell analysis of human mononuclear phagocytes reveals subset-defining markers and identifies circulating inflammatory dendritic cells. Immunity. 2019;51:573–89.e8. [DOI] [PubMed]

Patel VI, Booth JL, Duggan ES, Cate S, White VL, Hutchings D, et al. Transcriptional classification and functional characterization of human airway macrophage and dendritic cell subsets. J Immunol. 2017;198:1183–201. [DOI] [PubMed] [PMC]

Bagdi E, Krenacs L, Krenacs T, Miller K, Isaacson PG. Follicular dendritic cells in reactive and neoplastic lymphoid tissues: a reevaluation of staining patterns of CD21, CD23, and CD35 antibodies in paraffin sections after wet heat-induced epitope retrieval. Appl Immunohistochem Mol Morphol. 2001;9:117–24. [DOI] [PubMed]

Oberlin D, Fellbaum C, Eppler E. Insulin-like growth factor I messenger RNA and protein are expressed in the human lymph node and distinctly confined to subtypes of macrophages, antigen-presenting cells, lymphocytes and endothelial cells. Immunology. 2009;128:342–50. [DOI] [PubMed] [PMC]

Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 2002;23:445–9. [DOI] [PubMed]

Lutz MB, Backer RA, Clausen BE. Revisiting current concepts on the tolerogenicity of steady-state dendritic cell subsets and their maturation stages. J Immunol. 2021;206:1681–9. [DOI] [PubMed]

10.

Hölken JM, Friedrich K, Merkel M, Blasius N, Engels U, Buhl T, et al. A human 3D immune competent full-thickness skin model mimicking dermal dendritic cell activation. Front Immunol. 2023;14:1276151. [DOI] [PubMed] [PMC]

11.

Choreño-Parra JA, Cervantes-Rosete D, Jiménez-Álvarez LA, Ramírez-Martínez G, Márquez-García JE, Cruz-Lagunas A, et al. Dendritic cells drive profibrotic inflammation and aberrant T cell polarization in systemic sclerosis. Rheumatology (Oxford). 2023;62:1687–98. [DOI] [PubMed] [PMC]

12.

Papadaki G, Goutakoli P, Tiniakou I, Grün JR, Grützkau A, Pavlopoulos GA, et al. IL-6 signaling attenuates TNF-α production by plasmacytoid dendritic cells in rheumatoid arthritis. J Immunol. 2022;209:1906–17. [DOI] [PubMed]

13.

Scheinecker C, McHugh R, Shevach EM, Germain RN. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J Exp Med. 2002;196:1079–90. [DOI] [PubMed] [PMC]

14.

Aiba S. Maturation of dendritic cells induced by cytokines and haptens. Tohoku J Exp Med. 1998;184:159–72. [DOI] [PubMed]

15.

Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol. 1997;9:10–6. [DOI] [PubMed]

16.

van Kooten C, Banchereau J. Functions of CD40 on B cells, dendritic cells and other cells. Curr Opin Immunol. 1997;9:330–7. [DOI] [PubMed]

17.

Roy M, Waldschmidt T, Aruffo A, Ledbetter JA, Noelle RJ. The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4⁺ T cells. J Immunol. 1993;151:2497–510. [PubMed]

18.

Pitzalis C, Jones GW, Bombardieri M, Jones SA. Ectopic lymphoid-like structures in infection, cancer and autoimmunity. Nat Rev Immunol. 2014;14:447–62. [DOI] [PubMed]

19.

Rangel-Moreno J, Hartson L, Navarro C, Gaxiola M, Selman M, Randall TD. Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. J Clin Invest. 2006;116:3183–94. [DOI] [PubMed] [PMC]

20.

Moyron-Quiroz JE, Rangel-Moreno J, Kusser K, Hartson L, Sprague F, Goodrich S, et al. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat Med. 2004;10:927–34. [DOI] [PubMed]

21.

Allen CD, Cyster JG. Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol. 2008;20:14–25. [DOI] [PubMed] [PMC]

22.

Grayson MH, Ramos MS, Rohlfing MM, Kitchens R, Wang HD, Gould A, et al. Controls for lung dendritic cell maturation and migration during respiratory viral infection. J Immunol. 2007;179:1438–48. [DOI] [PubMed]

23.

Schuurhuis DH, Fu N, Ossendorp F, Melief CJ. Ins and outs of dendritic cells. Int Arch Allergy Immunol. 2006;140:53–72. [DOI] [PubMed]

24.

Hughes CE, Benson RA, Bedaj M, Maffia P. Antigen-presenting cells and antigen presentation in tertiary lymphoid organs. Front Immunol. 2016;7:481. [DOI] [PubMed] [PMC]

25.

Xue D, Lu S, Zhang H, Zhang L, Dai Z, Kaufman DS, et al. Induced pluripotent stem cell-derived engineered T cells, natural killer cells, macrophages, and dendritic cells in immunotherapy. Trends Biotechnol. 2023;41:907–22. [DOI] [PubMed]

26.

Chhabra A, Chen IP, Batra D. Human dendritic cell-derived induced pluripotent stem cell lines are not immunogenic. J Immunol. 2017;198:1875–86.

27.

Upham JW, Xi Y. Dendritic cells in human lung disease: recent advances. Chest. 2017;151:668–73. [DOI] [PubMed]

28.

van Helden MJ, Lambrecht BN. Dendritic cells in asthma. Curr Opin Immunol. 2013;25:745–54. [DOI] [PubMed]

29.

Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, et al. SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity. Nature. 2023;620:200–8. [DOI] [PubMed] [PMC]

30.

Chiu BC, Freeman CM, Stolberg VR, Hu JS, Komuniecki E, Chensue SW. The innate pulmonary granuloma: characterization and demonstration of dendritic cell recruitment and function. Am J Pathol. 2004;164:1021–30. [DOI] [PubMed] [PMC]

31.

Traidl-Hoffmann C, Mariani V, Hochrein H, Karg K, Wagner H, Ring J, et al. Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J Exp Med. 2005;201:627–36. [DOI] [PubMed] [PMC]

32.

Kaliński P, Schuitemaker JH, Hilkens CM, Kapsenberg ML. Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J Immunol. 1998;161:2804–9. [PubMed]

33.

de Heer HJ, Hammad H, Soullié T, Hijdra D, Vos N, Willart MA, et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med. 2004;200:89–98. [DOI] [PubMed] [PMC]

34.

Ito T, Amakawa R, Inaba M, Hori T, Ota M, Nakamura K, et al. Plasmacytoid dendritic cells regulate Th cell responses through OX40 ligand and type I IFNs. J Immunol. 2004;172:4253–9. [DOI] [PubMed]

35.

Guerrero-Plata A, Kolli D, Hong C, Casola A, Garofalo RP. Subversion of pulmonary dendritic cell function by paramyxovirus infections. J Immunol. 2009;182:3072–83. [DOI] [PubMed] [PMC]

36.

Ah Kioon MD, Tripodo C, Fernandez D, Kirou KA, Spiera RF, Crow MK, et al. Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8. Sci Transl Med. 2018;10:eaam8458. [DOI] [PubMed] [PMC]

37.

Pietraforte I, Butera A, Gaddini L, Mennella A, Palazzo R, Campanile D, et al. CXCL4-RNA complexes circulate in systemic sclerosis and amplify inflammatory/pro-fibrotic responses by myeloid dendritic cells. Int J Mol Sci. 2022;24:653. [DOI] [PubMed] [PMC]

38.

Deb P, Dai J, Singh S, Kalyoussef E, Fitzgerald-Bocarsly P. Triggering of the cGAS-STING pathway in human plasmacytoid dendritic cells inhibits TLR9-mediated IFN production. J Immunol. 2020;205:223–36. [DOI] [PubMed] [PMC]

39.

Lynch JP, Mazzone SB, Rogers MJ, Arikkatt JJ, Loh Z, Pritchard AL, et al. The plasmacytoid dendritic cell: at the cross-roads in asthma. Eur Respir J. 2014;43:264–75. [DOI] [PubMed]

40.

Chen K, Liu M, Liu Y, Wang C, Yoshimura T, Gong W, et al. Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation. J Biol Chem. 2013;288:16262–73. [DOI] [PubMed] [PMC]

41.

Sung SS, Fu SM, Rose CE Jr, Gaskin F, Ju ST, Beaty SR. A major lung CD103 (α_E)-β₇ integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol. 2006;176:2161–72. [DOI] [PubMed]

42.

Bleck B, Tse DB, Jaspers I, Curotto de Lafaille MA, Reibman J. Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation. J Immunol. 2006;176:7431–7. [DOI] [PubMed]

43.

Holt PG. Regulation of antigen-presenting cell function(s) in lung and airway tissues. Eur Respir J. 1993;6:120–9. [PubMed]

44.

Masten BJ, Olson GK, Tarleton CA, Rund C, Schuyler M, Mehran R, et al. Characterization of myeloid and plasmacytoid dendritic cells in human lung. J Immunol. 2006;177:7784–93. [DOI] [PubMed]

45.

Youkeles LH, Grizzanti JN, Liao Z, Chang CJ, Rosenstreich DL. Decreased tobacco-glycoprotein-induced lymphocyte proliferation in vitro in pulmonary eosinophilic granuloma. Am J Respir Crit Care Med. 1995;151:145–50. [DOI] [PubMed]

46.

Koethe SM, Kuhnmuench JR, Becker CG. Neutrophil priming by cigarette smoke condensate and a tobacco anti-idiotypic antibody. Am J Pathol. 2000;157:1735–43. [DOI] [PubMed] [PMC]

47.

Bagdonas E, Raudoniute J, Bruzauskaite I, Aldonyte R. Novel aspects of pathogenesis and regeneration mechanisms in COPD. Int J Chron Obstruct Pulmon Dis. 2015;10:995–1013. [DOI] [PubMed] [PMC]

48.

Soriano JB, Polverino F, Cosio BG. What is early COPD and why is it important? Eur Respir J. 2018;52:1801448. [DOI] [PubMed]

49.

Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol. 2009;4:435–59. [DOI] [PubMed]

50.

Vassallo R, Kroening PR, Parambil J, Kita H. Nicotine and oxidative cigarette smoke constituents induce immune-modulatory and pro-inflammatory dendritic cell responses. Mol Immunol. 2008;45:3321–9. [DOI] [PubMed] [PMC]

51.

Stoll P, Heinz AS, Bratke K, Bier A, Garbe K, Kuepper M, et al. Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD. Respir Res. 2014;15:48. [DOI] [PubMed] [PMC]

52.

Metcalfe HJ, Lea S, Hughes D, Khalaf R, Abbott-Banner K, Singh D. Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages. Clin Exp Immunol. 2014;176:461–72. [DOI] [PubMed] [PMC]

53.

Arellano-Orden E, Calero-Acuña C, Moreno-Mata N, Gómez-Izquierdo L, Sánchez-López V, López-Ramírez C, et al. Cigarette smoke decreases the maturation of lung myeloid dendritic cells. PLoS One. 2016;11:e0152737. [DOI] [PubMed] [PMC]

54.

Bratke K, Klug M, Bier A, Julius P, Kuepper M, Virchow JC, et al. Function-associated surface molecules on airway dendritic cells in cigarette smokers. Am J Respir Cell Mol Biol. 2008;38:655–60. [DOI] [PubMed]

55.

Mori M, Andersson CK, Svedberg KA, Glader P, Bergqvist A, Shikhagaie M, et al. Appearance of remodelled and dendritic cell-rich alveolar-lymphoid interfaces provides a structural basis for increased alveolar antigen uptake in chronic obstructive pulmonary disease. Thorax. 2013;68:521–31. [DOI] [PubMed]

56.

Vassallo R, Walters PR, Lamont J, Kottom TJ, Yi ES, Limper AH. Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study. Respir Res. 2010;11:45. [DOI] [PubMed] [PMC]

57.

Freeman CM, Curtis JL. Lung dendritic cells: shaping immune responses throughout chronic obstructive pulmonary disease progression. Am J Respir Cell Mol Biol. 2017;56:152–9. [DOI] [PubMed] [PMC]

58.

Givi ME, Peck MJ, Boon L, Mortaz E. The role of dendritic cells in the pathogenesis of cigarette smoke-induced emphysema in mice. Eur J Pharmacol. 2013;721:259–66. [DOI] [PubMed]

59.

Zhou JS, Li ZY, Xu XC, Zhao Y, Wang Y, Chen HP, et al. Cigarette smoke-initiated autoimmunity facilitates sensitisation to elastin-induced COPD-like pathologies in mice. Eur Respir J. 2020;56:2000404. [DOI] [PubMed]

60.

Gu BH, Sprouse ML, Madison MC, Hong MJ, Yuan X, Tung HY, et al. A novel animal model of emphysema induced by anti-elastin autoimmunity. J Immunol. 2019;203:349–59. [DOI] [PubMed] [PMC]

61.

Mehraban S, Gu G, Ma S, Liu X, Turino G, Cantor J. The proinflammatory activity of structurally altered elastic fibers. Am J Respir Cell Mol Biol. 2020;63:699–706. [DOI] [PubMed]

62.

Fagiola M, Gu G, Avella J, Cantor J. Free lung desmosine: a potential biomarker for elastic fiber injury in pulmonary emphysema. Biomarkers. 2022;27:319–24. [DOI] [PubMed]

63.

Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004;350:2645–53. [DOI] [PubMed]

64.

Egeler RM, Favara BE, van Meurs M, Laman JD, Claassen E. Differential in situ cytokine profiles of Langerhans-like cells and T cells in Langerhans cell histiocytosis: abundant expression of cytokines relevant to disease and treatment. Blood. 1999;94:4195–201. [PubMed]

65.

Kobayashi M, Tojo A. Langerhans cell histiocytosis in adults: advances in pathophysiology and treatment. Cancer Sci. 2018;109:3707–13. [DOI] [PubMed] [PMC]

66.

Jouenne F, Benattia A, Tazi A. Mitogen-activating protein kinase pathway alterations in Langerhans cell histiocytosis. Curr Opin Oncol. 2021;33:101–9. [DOI] [PubMed]

67.

Collin M, Bigley V, McClain KL, Allen CE. Cell(s) of origin of Langerhans cell histiocytosis. Clin North Am. 2015;29:825–38. [DOI] [PubMed] [PMC]

68.

Hutter C, Kauer M, Simonitsch-Klupp I, Jug G, Schwentner R, Leitner J, et al. Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells. Blood. 2012;120:5199–208. [DOI] [PubMed]

69.

Popper H, Knipping G, Czarnetzki BM, Steiner R, Helleis G, Auer H. Activation and release of enzymes and major basic protein from guinea pig eosinophil granulocytes induced by different inflammatory stimuli and other substances. A histochemical, biochemical, and electron microscopic study. Inflammation. 1989;13:147–62. [DOI] [PubMed]

70.

Popper HH. Pulmonary Langerhans cell histiocytosis. Pathologe. 2015;36:451–7. German. [DOI] [PubMed]

71.

Annels NE, Da Costa CE, Prins FA, Willemze A, Hogendoorn PC, Egeler RM. Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of Langerhans cell histiocytosis. J Exp Med. 2003;197:1385–90. [DOI] [PubMed] [PMC]

72.

Masunaga A, Takemura T, Ichiyasu H, Migiyama E, Horio Y, Saeki S, et al. Pathological and clinical relevance of selective recruitment of Langerhans cells in the respiratory bronchioles of smokers. Respir Investig. 2021;59:513–21. [DOI] [PubMed]

73.

Keicho N, Ohashi J, Tamiya G, Nakata K, Taguchi Y, Azuma A, et al. Fine localization of a major disease-susceptibility locus for diffuse panbronchiolitis. Am J Hum Genet. 2000;66:501–7. [DOI] [PubMed] [PMC]

74.

Kontakioti E, Domvri K, Papakosta D, Daniilidis M. HLA and asthma phenotypes/endotypes: a review. Hum Immunol. 2014;75:930–9. [DOI] [PubMed]

75.

Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet. 2008;372:1107–19. [DOI] [PubMed]

76.

Castro-Rodriguez JA, Forno E, Rodriguez-Martinez CE, Celedón JC. Risk and protective factors for childhood asthma: What is the evidence? J Allergy Clin Immunol Pract. 2016;4:1111–22. [DOI] [PubMed] [PMC]

77.

Wang IJ, Karmaus WJ, Yang CC. Polycyclic aromatic hydrocarbons exposure, oxidative stress, and asthma in children. Int Arch Occup Environ Health. 2017;90:297–303. [DOI] [PubMed]

78.

Zahiruddin AS, Grant JA, Sur S. Role of epigenetics and DNA-damage in asthma. Curr Opin Allergy Clin Immunol. 2018;18:32–7. [DOI] [PubMed]

79.

Hall S, Agrawal DK. Key mediators in the immunopathogenesis of allergic asthma. Int Immunopharmacol. 2014;23:316–29. [DOI] [PubMed] [PMC]

80.

Erle DJ, Sheppard D. The cell biology of asthma. J Cell Biol. 2014;205:621–31. [DOI] [PubMed] [PMC]

81.

DeKruyff RH, Yu S, Kim HY, Umetsu DT. Innate immunity in the lung regulates the development of asthma. Immunol Rev. 2014;260:235–48. [DOI] [PubMed]

82.

Holgate ST. Mechanisms of asthma and implications for its prevention and treatment: a personal journey. Allergy Asthma Immunol Res. 2013;5:343–7. [DOI] [PubMed] [PMC]

83.

Lambrecht BN, Hammad H. Asthma: the importance of dysregulated barrier immunity. Eur J Immunol. 2013;43:3125–37. [DOI] [PubMed]

84.

Gaurav R, Agrawal DK. Clinical view on the importance of dendritic cells in asthma. Expert Rev Clin Immunol. 2013;9:899–919. [DOI] [PubMed] [PMC]

85.

Kumar Y, Bhatia A. Immunopathogenesis of allergic disorders: current concepts. Expert Rev Clin Immunol. 2013;9:211–26. [DOI] [PubMed]

86.

Grotenboer NS, Ketelaar ME, Koppelman GH, Nawijn MC. Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology. J Allergy Clin Immunol. 2013;131:856–65. [DOI] [PubMed]

87.

Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, et al. Muc5b is required for airway defence. Nature. 2014;505:412–6. [DOI] [PubMed] [PMC]

88.

Jackola DR. Random allergen-specific IgE expression in atopic families: evidence for inherited “stochastic bias” in adverse immune response development to non-infectious antigens. Mol Immunol. 2007;44:2549–57. [DOI] [PubMed] [PMC]

89.

Tan J, Bernstein JA. Occupational asthma: an overview. Curr Allergy Asthma Rep. 2014;14:431. [DOI] [PubMed]

90.

Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007;104:15858–63. [DOI] [PubMed] [PMC]

91.

Holtzman MJ, Byers DE, Alexander-Brett J, Wang X. The role of airway epithelial cells and innate immune cells in chronic respiratory disease. Nat Rev Immunol. 2014;14:686–98. [DOI] [PubMed] [PMC]

92.

Kumar RK, Foster PS, Rosenberg HF. Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations. J Leukoc Biol. 2014;96:391–6. [DOI] [PubMed] [PMC]

93.

Vadasz Z, Haj T, Toubi E. The role of B regulatory cells and Semaphorin3A in atopic diseases. Int Arch Allergy Immunol. 2014;163:245–51. [DOI] [PubMed]

94.

Heijink IH, Nawijn MC, Hackett TL. Airway epithelial barrier function regulates the pathogenesis of allergic asthma. Clin Exp Allergy. 2014;44:620–30. [DOI] [PubMed]

95.

Vermeer PD, Denker J, Estin M, Moninger TO, Keshavjee S, Karp P, et al. MMP9 modulates tight junction integrity and cell viability in human airway epithelia. Am J Physiol Lung Cell Mol Physiol. 2009;296:L751–62. [DOI] [PubMed] [PMC]

96.

de Boer WI, Sharma HS, Baelemans SM, Hoogsteden HC, Lambrecht BN, Braunstahl GJ. Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation. Can J Physiol Pharmacol. 2008;86:105–12. [DOI] [PubMed]

97.

Yu S, Kim HY, Chang YJ, DeKruyff RH, Umetsu DT. Innate lymphoid cells and asthma. J Allergy Clin Immunol. 2014;133:943–50. [DOI] [PubMed]

98.

Alexis NE, Carlsten C. Interplay of air pollution and asthma immunopathogenesis: a focused review of diesel exhaust and ozone. Int Immunopharmacol. 2014;23:347–55. [DOI] [PubMed]

99.

Message SD, Johnston SL. The immunology of virus infection in asthma. Eur Respir J. 2001;18:1013–25. [DOI] [PubMed]

100.

Popper H. Experimental monoarthritis. Modulatory effect of injected eosinophils on influx of various types of inflammatory cells. Inflammation. 1984;8:301–12. [DOI] [PubMed]

101.

Fattahi F, Vonk JM, Bulkmans N, Fleischeuer R, Gouw A, Grünberg K, et al. Old dilemma: asthma with irreversible airway obstruction or COPD. Virchows Arch. 2015;467:583–93. [DOI] [PubMed] [PMC]

102.

Veress B, Malmsköld K. The distribution of S100 and lysozyme immunoreactive cells in the various phases of granuloma development in sarcoidosis. Sarcoidosis. 1987;4:33–7. [PubMed]

103.

Lommatzsch M, Bratke K, Bier A, Julius P, Kuepper M, Luttmann W, et al. Airway dendritic cell phenotypes in inflammatory diseases of the human lung. Eur Respir J. 2007;30:878–86. [DOI] [PubMed]

104.

Ota M, Amakawa R, Uehira K, Ito T, Yagi Y, Oshiro A, et al. Involvement of dendritic cells in sarcoidosis. Thorax. 2004;59:408–13. [DOI] [PubMed] [PMC]

105.

Ten Berge B, Kleinjan A, Muskens F, Hammad H, Hoogsteden HC, Hendriks RW, et al. Evidence for local dendritic cell activation in pulmonary sarcoidosis. Respir Res. 2012;13:33. [DOI] [PubMed] [PMC]

106.

Franzen DP, Brutsche M, Nilsson J, Böni C, Daccord C, Distler O, et al. Sarcoidosis–a multisystem disease. Swiss Med Wkly. 2022;152:w30049. [DOI] [PubMed]

107.

Wilde B, van Paassen P, Damoiseaux J, Heerings-Rewinkel P, van Rie H, Witzke O, et al. Dendritic cells in renal biopsies of patients with ANCA-associated vasculitis. Nephrol Dial Transplant. 2009;24:2151–6. [DOI] [PubMed]

108.

Eloranta ML, Franck-Larsson K, Lövgren T, Kalamajski S, Rönnblom A, Rubin K, et al. Type I interferon system activation and association with disease manifestations in systemic sclerosis. Ann Rheum Dis. 2010;69:1396–402. [DOI] [PubMed]

109.

Carvalheiro T, Zimmermann M, Radstake TRDJ, Marut W. Novel insights into dendritic cells in the pathogenesis of systemic sclerosis. Clin Exp Immunol. 2020;201:25–33. [DOI] [PubMed] [PMC]

110.

Chaudhary V, Ah Kioon MD, Hwang SM, Mishra B, Lakin K, Kirou KA, et al. Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses. J Exp Med. 2022;219:e20221085. [DOI] [PubMed] [PMC]

111.

van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, et al. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014;370:433–43. [DOI] [PubMed] [PMC]

112.

Affandi AJ, Carvalheiro T, Ottria A, Broen JC, Bossini-Castillo L, Tieland RG, et al. Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis. Ann Rheum Dis. 2019;78:1249–59. [DOI] [PubMed]

113.

Chouri E, Wang M, Hillen MR, Angiolilli C, Silva-Cardoso SC, Wichers CGK, et al. Implication of miR-126 and miR-139-5p in plasmacytoid dendritic cell dysregulation in systemic sclerosis. J Clin Med. 2021;10:491. [DOI] [PubMed] [PMC]

114.

Popper H, Stacher-Priehse E, Brcic L, Nerlich A. Lung fibrosis in autoimmune diseases and hypersensitivity: how to separate these from idiopathic pulmonary fibrosis. Rheumatol Int. 2022;42:1321–30. [DOI] [PubMed] [PMC]

115.

Walker JG, Ahern MJ, Coleman M, Weedon H, Papangelis V, Beroukas D, et al. Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/STAT transcription factors from patients with rheumatoid arthritis. Ann Rheum Dis. 2007;66:992–9. [DOI] [PubMed] [PMC]

116.

Coutant F. Shaping of monocyte-derived dendritic cell development and function by environmental factors in rheumatoid arthritis. Int J Mol Sci. 2021;22:13670. [DOI] [PubMed] [PMC]

117.

Yamada S, Nagafuchi Y, Wang M, Ota M, Hatano H, Takeshima Y, et al. Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance. Ann Rheum Dis. 2023;82:809–19. [DOI] [PubMed] [PMC]

118.

Suwa Y, Nagafuchi Y, Yamada S, Fujio K. The role of dendritic cells and their immunometabolism in rheumatoid arthritis. Front Immunol. 2023;14:1161148. [DOI] [PubMed] [PMC]

119.

Meng Y, Ma J, Yao C, Ye Z, Ding H, Liu C, et al. The NCF1 variant p.R90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells. J Clin Invest. 2022;132:e153619. [DOI] [PubMed] [PMC]

120.

Kim JM, Park SH, Kim HY, Kwok SK. A Plasmacytoid dendritic cells-type I interferon axis is critically implicated in the pathogenesis of systemic lupus erythematosus. Int J Mol Sci. 2015;16:14158–70. [DOI] [PubMed] [PMC]

121.

Wardowska A, Smoleńska Ż, Lisowska KA, Zdrojewski Z, Pikuła M. Dendritic cells’ characteristics in patients with treated systemic lupus erythematosus. Acta Biochim Pol. 2020;67:417–29. [DOI] [PubMed]

122.

King JK, Philips RL, Eriksson AU, Kim PJ, Halder RC, Lee DJ, et al. Langerhans cells maintain local tissue tolerance in a model of systemic autoimmune disease. J Immunol. 2015;195:464–76. [DOI] [PubMed] [PMC]

123.

Cai Y, Yang C, Yu X, Qian J, Dai M, Wang Y, et al. Deficiency of β-arrestin 2 in dendritic cells contributes to autoimmune diseases. J Immunol. 2019;202:407–20. [DOI] [PubMed]

124.

Kim EA, Lee KS, Johkoh T, Kim TS, Suh GY, Kwon OJ, et al. Interstitial lung diseases associated with collagen vascular diseases: radiologic and histopathologic findings. Radiographics. 2002;22:S151–65. [DOI] [PubMed]

125.

Chen Z, Cao M, Plana MN, Liang J, Cai H, Kuwana M, et al. Utility of anti-melanoma differentiation-associated gene 5 antibody measurement in identifying patients with dermatomyositis and a high risk for developing rapidly progressive interstitial lung disease: a review of the literature and a meta-analysis. Arthritis Care Res (Hoboken). 2013;65:1316–24. [DOI] [PubMed]

126.

Thuner J, Coutant F. IFN-γ: an overlooked cytokine in dermatomyositis with anti-MDA5 antibodies. Autoimmun Rev. 2023;22:103420. [DOI] [PubMed]

127.

Shen N, Zhou X, Jin X, Lu C, Hu X, Zhang Y, et al. MDA5 expression is associated with TGF-β-induced fibrosis: potential mechanism of interstitial lung disease in anti-MDA5 dermatomyositis. Rheumatology (Oxford). 2022;62:373–83. [DOI] [PubMed]

128.

McPherson M, Economidou S, Liampas A, Zis P, Parperis K. Management of MDA-5 antibody positive clinically amyopathic dermatomyositis associated interstitial lung disease: a systematic review. Semin Arthritis Rheum. 2022;53:151959. [DOI] [PubMed]

129.

Douglas WW, Tazelaar HD, Hartman TE, Hartman RP, Decker PA, Schroeder DR, et al. Polymyositis-dermatomyositis-associated interstitial lung disease. Am J Respir Crit Care Med. 2001;164:1182–5. [DOI] [PubMed]

130.

Liu Y, Feng S, Liu X, Tang Y, Li X, Luo C, et al. IFN-beta and EIF2AK2 are potential biomarkers for interstitial lung disease in anti-MDA5 positive dermatomyositis. Rheumatology (Oxford). 2023;62:3724–31. [DOI] [PubMed]

131.

Chen KL, Patel J, Zeidi M, Wysocka M, Bashir MM, Patel B, et al. Myeloid dendritic cells are major producers of IFN-β in dermatomyositis and may contribute to hydroxychloroquine refractoriness. J Invest Dermatol. 2021;141:1906–14.e2. [DOI] [PubMed] [PMC]

132.

Khanna S, Reed AM. Immunopathogenesis of juvenile dermatomyositis. Muscle Nerve. 2010;41:581–92. [DOI] [PubMed]

133.

de Padilla CM, Reed AM. Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies. Curr Opin Rheumatol. 2008;20:669–74. [DOI] [PubMed]

134.

Turnier JL, Yee CM, Madison JA, Rizvi SM, Berthier CC, Wen F, et al. Imaging mass cytometry reveals predominant innate immune signature and endothelial-immune cell interaction in juvenile myositis compared to lupus skin. Arthritis Rheumatol. 2022;74:2024–31. [DOI] [PubMed] [PMC]

135.

Lv J, Li L, Li W, Ji K, Hou Y, Yan C, et al. Role of the chemokine receptors CXCR3, CXCR4 and CCR7 in the intramuscular recruitment of plasmacytoid dendritic cells in dermatomyositis. J Neuroimmunol. 2018;319:142–8. [DOI] [PubMed]

136.

Gendek-Kubiak H, Gendek EG. Fascin-expressing dendritic cells dominate in polymyositis and dermatomyositis. J Rheumatol. 2013;40:186–91. [DOI] [PubMed]

137.

Page G, Chevrel G, Miossec P. Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis: Interaction with chemokines and Th1 cytokine-producing cells. Arthritis Rheum. 2004;50:199–208. [DOI] [PubMed]

138.

Wang Y, Roussel-Queval A, Chasson L, Hanna Kazazian N, Marcadet L, Nezos A, et al. TLR7 signaling drives the development of Sjögren’s syndrome. Front Immunol. 2021;12:676010. [DOI] [PubMed] [PMC]

139.

Bernatchez E, Langlois A, Brassard J, Flamand N, Marsolais D, Blanchet MR. Hypersensitivity pneumonitis onset and severity is regulated by CD103 dendritic cell expression. PLoS One. 2017;12:e0179678. [DOI] [PubMed] [PMC]

140.

Pardo A, Smith KM, Abrams J, Coffman R, Bustos M, McClanahan TK, et al. CCL18/DC-CK-1/PARC up-regulation in hypersensitivity pneumonitis. J Leukoc Biol. 2001;70:610–6. [PubMed]

141.

Vo MC, Lee HJ, Kim JS, Hoang MD, Choi NR, Rhee JH, et al. Dendritic cell vaccination with a toll-like receptor agonist derived from mycobacteria enhances anti-tumor immunity. Oncotarget. 2015;6:33781–90. [DOI] [PubMed] [PMC]

142.

Xiang R, Luo Y, Niethammer AG, Reisfeld RA. Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis. Immunol Rev. 2008;222:117–28. [DOI] [PubMed]

143.

Mogrão J, da Costa CA, Gaspar R, Florindo HF. Modulation of dendritic cells by nanotechnology-based immunotherapeutic strategies. J Biomed Nanotechnol. 2016;12:405–34. [DOI] [PubMed]

144.

Gonzalez-Gugel E, Saxena M, Bhardwaj N. Modulation of innate immunity in the tumor microenvironment. Cancer Immunol Immunother. 2016;65:1261–8. [DOI] [PubMed] [PMC]

145.

Benencia F, Muccioli M, Alnaeeli M. Perspectives on reprograming cancer-associated dendritic cells for anti-tumor therapies. Front Oncol. 2014;4:72. [DOI] [PubMed] [PMC]

146.

Sung E, Ko M, Won JY, Jo Y, Park E, Kim H, et al. LAG-3xPD-L1 bispecific antibody potentiates antitumor responses of T cells through dendritic cell activation. Mol Ther. 2022;30:2800–16. [DOI] [PubMed] [PMC]

147.

Funes SC, Ríos M, Gómez-Santander F, Fernández-Fierro A, Altamirano-Lagos MJ, Rivera-Perez D, et al. Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice. Immunology. 2019;158:322–39. [DOI] [PubMed] [PMC]

148.

Rosen SJ, Harris PE, Hardy MA. State of the art: role of the dendritic cell in induction of allograft tolerance. Transplantation. 2018;102:1603–13. [DOI] [PubMed] [PMC]