Role of NEAT1 in different autoimmune diseases
| Disease type | Effects of NEAT1 | Reference |
|---|---|---|
| Systemic lupus erythematosus | Upregulation of the activation of MAPK signaling pathway in TLR4-mediated inflammatory process; | Zhang et al. [20] |
| Upregulation of chemokines and cytokines; | Xiang et al. [21] | |
| Abnormal activation of IFN-I signaling. | Dong et al. [23] | |
| Rheumatoid arthritis (RA) | Regulating glutamine metabolism and FLSs-RA dysfunction in FLSs of RA; | Wang et al. [26] |
| Influencing FLSs physiological function by inhibiting miR-23a expression; | Wade et al. [27] andZhao et al. [28] | |
| Regulating the NF-κB signaling pathway; | Kawahara et al. [30] | |
| Influence of CD4+ T cells differentiation into Th17 cells; | Liu et al. [32] and Shui et al. [33] | |
| RA aggravation via p300/CBP/IL-18 axis. | Guo et al. [6] | |
| Psoriasis | Upregulation of inflammatory factors; | Jin et al. [35] |
| Controlling the proliferation and differentiation of epidermal cells by interacting with miRNA. | Wang et al. [36] and Tang et al. [37] | |
| Multiple sclerosis | Regulating the imbalance of Th1/Th2; | Karimi et al. [40] |
| Upregulation of TNF-α and IL-17. | Li et al. [41] |
NEAT1: nuclear paraspeckle assembly transcript 1; MAPK: mitogen-activated protein kinases; FLSs: fibroblast-like synoviocytes; NF-κB: nuclear factor κB