Exploration of Immunology

From: Association of genetic variations of interleukin-6 polymorphism (rs1800795) with susceptibility to Hashimoto’s thyroiditis in West Algerian population

Table 6

Allelic results of IL-6 (-174 G/C) polymorphism in the literature

*Allelic studies of IL-6* (-174 G>C)**		Allele	Frequency
Our study (West Algeria)	Controls N = 211	G	375/422 (88.8%)
		C	47/422 (11.1%)
		G carriers	209/211 (99%)
		C carriers	43/211 (20.4%)
	Patients N = 81	G	146/162 (90.1%)
		C	16/162 (9.8%)
		G carriers	81/81 (100%)
		C carriers	16/81 (19.8%)
Erdogan et al. [16] (Turkey)	Controls N = 110	G	96 (43.6%)
	Controls N = 110	C	124 (56.4%)
	Patients N = 110	G	105 (47.7%)
	Patients N = 110	C	115 (52.3%)
Durães et al. [18] (Portugal)	Controls N = 735	log-additive (G/C)	962 (65.4%)/508 (35.6%)
	Controls N = 735	C carriers vs. GG	416 (56.6%)/319 (43.4%)
	Patients N = 418	Log-additive (G/C)	501 (59.9%)/335 (40.1%)^*
	Patients N = 418	C carriers vs. GG	262 (62.7%)/156 (37.3%)
Baki et al. [17] (Turkey)	Controls N = 231	G	74%
	Controls N = 231	C	26%
	Patients N = 190	G	88%
	Patients N = 190	C	22%
Aberkan [19] (Blida, center of Algeria)	Controls N = 35	G	60 (85.71%)
	Controls N = 35	C	10 (14.29%)
	Patients N = 27	G	43 (79.63%)
	Patients N = 27	C	11 (20.37%)

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^* Results statistically significant (P value < 0.05). IL-6: interleukin-6