ROC analysis of RPL and non-RPL group
| S. No. | Parameters | AUC | Sp (%) | Sn (%) | 95% CI | Cut-off | P value |
|---|---|---|---|---|---|---|---|
| 1. | TNF-α | 0.931 | 96 | 88 | 0.90–0.95 | 199.6 | *** |
| 2. | TGF-β | 0.930 | 82.76 | 93.4 | 0.91–0.95 | 635.9 | *** |
| 3. | TNF-α/TGF-β | 0.966 | 96 | 92.5 | 0.94–0.98 | 0.318 | *** |
| 4. | NLR | 0.6 | 27.14 | 92.61 | 0.54–0.65 | 2.278 | 0.0007 |
ROC characteristics to assess the diagnostic potential of parameters. ROC: receiver operating curve; RPL: recurrent pregnancy loss; AUC: area under curve; Sp: specificity; Sn: sensitivity; CI: confidence interval; ***: P < 0.0001
We are grateful to the blood donors who have helped us with this study. During the preparation of this work, authors used the Quillbot for improving the readability and fluency of the language. After using the Quillbot, authors reviewed and edited the content as needed and take full responsibility for the content of the publication.
RB: Investigation, Methodology, Project administration, Resources, Software, Writing—original draft, Data curation, Formal analysis. SJ: Data curation, Formal analysis. FR: Writing—review & editing. RB: Methodology, Resources. PJ: Conceptualization, Visualization, Writing—original draft, Writing—review & editing. Prior to submission, the work was reviewed and approved by all authors.
The authors declare that they have no conflicts of interest.
This study was approved by the Institutional Ethical Committee from Osmania Medical College, Hyderabad, Telangana-500028, India (Ethical approval reference no: Reg No: ECR/300/Inst/AP/2013/RR-16).
Informed consent to participate in the study was obtained from all participants.
Not applicable
The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.
This research was funded by the Indian Council for Medical Research (ICMR ID no. [2019-1022]), New Delhi, India. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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