Baseline clinical characteristics of patients with sepsis
| Characteristics | Total (n = 288) | P value | |
|---|---|---|---|
| Tα1 group (n = 149) | Placebo group (n = 139) | ||
| Age (years) | 65.1 ± 13.9 | 66.8 ± 12.4 | 0.276 |
| Sex (male) | 118 (79) | 100 (72) | 0.152 |
| Pre-existing conditions | 125 (84) | 113 (81) | 0.561 |
| Congestive cardiomyopathy | 3 | 4 | |
| Hypertension | 69 | 66 | |
| Coronary heart disease | 18 | 13 | |
| Liver disease | 7 | 7 | |
| COPD | 24 | 25 | |
| Diabetes | 34 | 28 | |
| Recent trauma | 7 | 5 | |
| Cancer | 50 | 42 | |
| Recent surgical history | 0.702 | ||
| No history of surgery | 77 | 78 | |
| Elective surgery | 39 | 35 | |
| Emergency surgery | 33 | 26 | |
| Other indicators of disease severity | 0.201 | ||
| MV | 118 | 108 | |
| Shock | 47 | 47 | |
| Use of vasopressor | 55 | 46 | |
| RRT | 24 | 13 | |
| Low dose corticoid | 16 | 12 | |
| Blood transfusion | 51 | 42 | |
| Acute organ dysfunctions | 0.303 | ||
| Pulmonary | 142 | 132 | |
| Renal | 41 | 34 | |
| Cardiovascular | 100 | 81 | |
| Hematological | 55 | 49 | |
| Hepatic | 23 | 24 | |
| Number of acute organ dysfunctions | 0.798 | ||
| 1 | 24 | 30 | |
| 2 | 64 | 59 | |
| 3 | 40 | 32 | |
| 4 | 16 | 14 | |
| 5 | 5 | 4 | |
| Site of infection | 0.598 | ||
| Lung | 113 | 105 | |
| Abdomen | 38 | 36 | |
| Positive blood culture | 9 | 7 | |
| Urinary tract | 2 | 5 | |
| Other | 11 | 11 | |
| Result of pathogens | 0.542 | ||
| Gram negative | 33 | 30 | |
| Gram positive | 9 | 13 | |
| Fungus | 15 | 18 | |
| Mixed | 59 | 56 | |
| No | 33 | 22 | |
| APACHE II score | 22.4 ± 6.3 | 21.2 ± 7.6 | 0.169 |
| C reactive protein (mg/L) | 129.0 (73.9, 189.5) | 114.0 (66.8, 175.5) | 0.153 |
| White blood cell (× 109/L) | 14.6 (10.2, 19.9) | 14.5 (11.0, 17.7) | 0.526 |
| Neutrophil (%) | 86.4 (80.8, 90.7) | 86.6 (80.9, 91.1) | 0.772 |
| Monocyte (%) | 5.0 (2.9, 7.5) | 4.9 (3.3, 7.4) | 0.865 |
| Lymphocyte (× 109/L) | 0.9 (0.5, 1.5) | 0.9 (0.5, 1.4) | 0.909 |
| Platelet (× 109/L) | 165.0 (86.3, 253.8) | 170.0 (116.0, 272.3) | 0.452 |
| Lactate (mmol/L) | 2.1 (1.3, 3.1) | 2.0 (1.3, 2.8) | 0.419 |
| Creatinine (μmol/L) | 102.9 (71.5, 196.3) | 93.0 (61.2, 180.2) | 0.183 |
| Total bilirubin (μmol/L) | 14.5 (9.2, 23.6) | 13.0 (8.4, 23.2) | 0.375 |
| ICU mortality | 7 (14.0) | 13 (13.1) | 0.884 |
| Hospital mortality | 10 (20.0) | 23 (23.2) | 0.652 |
| 28-day mortality | 8 (16.0) | 19 (19.2) | 0.630 |
| ICU-free days (median, IQR) | 17.8 (11.3, 20.4) | 11.8 (0.9, 18.3) | 0.001 |
| MV free days (median, IQR) | 21.0 (16.3, 25.5) | 19.4 (10.8, 24.9) | 0.275 |
Values are described by number (percentage), mean ± SD or median IQR. COPD: chronic obstructive pulmonary disease; RRT: renal replacement therapy; MV: mechanical ventilation