Examples of autoantibody generation in situations where an infectious component or a drug bind to a blood protein
| Disease | Antibody target | Clinical symptoms | Clinical severity | Antibody clearance (time) | Chronic autoimmune disease evolution |
|---|---|---|---|---|---|
| Oropharyngeal infection | PF4 | Cerebral and other thrombosis | + to +++ | 3–6 months | Unknown |
| Chicken pox | Protein S | Phlebitis, periheral thrombosis, renal failure, limb extremity necrosis | ++ to +++ | 3–6 months | Possible |
| Oropharyngeal infection | Prothrombin | Bruise, prolonged clotting time, bleeding | +/– to +++ | 3–6 months | Possible |
| EBV or CMV infection | GP IIb-IIIa | Thrombocytopenia | + to +++ | > 6 months | Frequent |
| Influenza infection, others | ADAMTS-13 | iTTP | ++ to +++ | Possible | |
| Healing with fibrin glue (bovine thrombin) | Thrombin | Thrombosis, DIC | ++ to +++ | > 3 months | Not reported |
| Various infections | B2-GP1, prothrombin | LA, prolonged clotting time, thrombosis, bruise | +/– to +++ | 3 to > 6 months | Possible |
| Autoimmune complications, lymphoproliferative disorders, others | Factor XIII | LA-like, delayed hemorrhagia | ++ to +++ | Under investigation | Possible |
| Antibiotherapy for antibioresistance | Factor V | Thrombosis, DIC | ++ to +++ | Unknown | Unknown |
EBV: Epstein-Bar virus; CMV: cyto megalo virus; iTTP: idiopathic thrombotic thrombocytopenic purpura; +: weak ; ++: moderate; +++: strong ; +/–: borderline