From:  Role of tumor necrosis factor receptor-associated factor 5 in B- and T-lymphocytes

TRAF5 and diseases in mice and humans

SpeciesDiseasesPhenotypesReferences
HumanASEnhanced methylation of CpG island of TRAF5 gene promoter and decreased TRAF5 gene expression in PBMCs[31]
RAA SNP mapping upstream of TRAF5 gene and affecting a putative transcription factor binding site[32]
UveitisSNPs in TRAF5 gene[33]
SSDecreased TRAF5 gene expression in the temporal bulbar conjunctiva[35]
SLEEnhanced TLR7 signaling caused by decreased expression of TRAF5 in B cells (pre-plasma cells)[36]
Coronary heart diseaseDecreased TRAF5 gene expression in the blood[21]
Obesity with a high cardiovascular riskDecreased TRAF5 gene expression in blood leukocytes and adipocytes[20]
NAFLDDecreased TRAF5 protein expression in the liver[23]
MouseAllergic asthmaEnhanced Th2 responses caused by Traf5-deficiency[18]
EAEEnhanced Th17 responses caused by Traf5-deficiency[13]
Wound healingIncreased pDC-mediated wound repair inflammatory responses caused by Traf5-deficiency[27]
AtherosclerosisEnhanced atherosclerosis caused by Traf5-deficiency[21]
Diet-induced obesityEnhanced diet-induced obesity and inflammation in the adipose tissue caused by Traf5-deficiency[20]
NAFLDEnhanced hepatic steatosis caused by Traf5-deficiency[23]
Myocardial ischemia-reperfusion injuryExacerbated inflammation and cell death after a myocardial ischemia-reperfusion injury caused by Traf5-deficiency[22]
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PBMCs: peripheral blood mononuclear cells