Exploration of Neuroprotective Therapy

Enriched process (glutamate overstimulation for 60 min)	Molecular mechanisms by affected by excitotoxicity
Protein localization at the membrane	Alterations in glutamate receptors (particularly NMDAR) and glutamate transporter functioning [9]
Organelle transportation along microtubule and regulation of cellular component movement	Changes in Ca²⁺ buffering and transposition of mitochondria [87]
Negative regulation of cellular amine metabolic	Over-recycling of glutamate in a dynamic pool, maintained through the glutamate-glutamine cycle by glutamine synthase in the cytoplasm of astrocytes and excitatory amino acid transporter dysfunction [88, 89]
Response processes to axon injury	Degeneration of axons and dendrites by a process associated with excessive increases in [Ca²⁺]_i and mitochondrial dysfunction [90]

Enriched process (glutamate overstimulation for 60 min)

Molecular mechanisms by affected by excitotoxicity

Protein localization at the membrane

Alterations in glutamate receptors (particularly NMDAR) and glutamate transporter functioning [9]

Organelle transportation along microtubule and regulation of cellular component movement

Changes in Ca²⁺ buffering and transposition of mitochondria [87]

Negative regulation of cellular amine metabolic

Over-recycling of glutamate in a dynamic pool, maintained through the glutamate-glutamine cycle by glutamine synthase in the cytoplasm of astrocytes and excitatory amino acid transporter dysfunction [88, 89]

Response processes to axon injury

Degeneration of axons and dendrites by a process associated with excessive increases in [Ca²⁺]_i and mitochondrial dysfunction [90]