Major findings supporting the involvement of CB2R in psychotic disorders
| Animal studies | ||||||
|---|---|---|---|---|---|---|
| Genetic studies | Genetic manipulation | Animal specie | Experimental test | Behavioral changes | References | |
| CB2–/– | Mouse, ICR | OF | ↑ sensibility to cocaine-induced hyperlocomotion | [44] | ||
| SDIA | short and long-term memory impairment | [44, 71] | ||||
| PPI | ↑ PPI | |||||
| Pharmacological studies | Drug | Animal specie | Experimental test | Dosis | Behavioral changes | References |
| AM630 (CB2R antagonist) | Mouse, C57BL/6J | PPI | 3 and 30 mg/kg | ↑ alteration induced by MK-801 | [42] | |
| Mouse, ICR | OF | 2 mg/kg | ↑ MK-801-induced hyperlocomotion | [70] | ||
| JWH015 (agonista CB2R) | Mouse, BALB/c | PPI | 1, 3 and 10 mg/kg | ↓ alteration induced by MK-801 | [67] | |
| JWH133 (agonista CB2R) | Mouse, ICR | OF | 20 mg/kg | ↓ cocaine-induced hyperlocomotion | [68] | |
| Mouse, C57BL/6J | OF | 10, 20 and 30 mg/kg | ↓ cocaine-induced hyperlocomotion | [69] | ||
| Human studies | |||
|---|---|---|---|
| Parameter | Population | Results | References |
| CB2R gene expression | Caucasian | ↓ reduction in PBMCs | [57] |
| Polymorphism | Population | Results | References |
| rs12744386 rs2501432 | Japanese | ↑ incidence | [42] |
| rs2501432 | Chinese (Han ethnic group) | Allele T ↑ risk | [58] |
| rs22229579 | Allele T ↓ risk | ||
| rs6689530 rs34570472 Cnr2_ht1 Cnr2_ht2 Cnr2_ht3 | Korean | No effect | [59] |
OF: open field test; SDIA: step-down inhibitory avoidance; PBMCs: peripheral blood mononuclear cells