Exploration of Neuroprotective Therapy

Table 2

MST metrics and mean comparison test results by group at time-point T1 = 10,000, T2 = 20,000, and T3 = 30,000

Metrics	Time	Group			Statistic		P-value
Metrics	Time	LT	RT	HC	AOV	Kruskal-Wallis	AOV	Kruskal-Wallis
Max of degree	T1	6.381 (1.203)	5.571 (0.978)	6.174 (1.141)	3.083	5.540	0.051	0.063
	T2	6.429 (1.165)	5.905 (1.091)	6.065 (1.000)	1.379	2.308	0.257	0.315
	T3	6.476 (1.436)	5.762 (1.044)	6.109 (1.100)	1.939	3.606	0.150	0.165
Max of BC	T1	0.627 (0.044)	0.648 (0.043)	0.632 (0.050)	1.172	3.168	0.315	0.205
	T2	0.648 (0.055)	0.648 (0.054)	0.635 (0.051)	0.613	1.082	0.544	0.582
	T3	0.636 (0.047)	0.631 (0.042)	0.640 (0.054)	0.187	0.217	0.830	0.897
Mean of BC	T1	0.098 (0.010)	0.102 (0.011)	0.095 (0.009)	4.620	7.901	0.012^*	0.019^*
	T2	0.093 (0.009)	0.102 (0.013)	0.095 (0.008)	5.183	6.469	0.008^*	0.040^*
	T3	0.101 (0.012)	0.100 (0.010)	0.095 (0.009)	3.449	7.902	0.036^*	0.019^*
Eccentricity	T1	14.612 (1.637)	15.183 (2.075)	14.304 (1.788)	1.670	3.181	0.194	0.204
	T2	13.928 (1.446)	15.126 (1.939)	14.261 (1.551)	3.139	5.224	0.048^*	0.073
	T3	15.033 (1.928)	15.085 (1.567)	14.280 (1.755)	2.166	5.843	0.121	0.054
Diameter	T1	18.620 (2.224)	19.524 (2.909)	18.478 (2.492)	1.267	2.634	0.287	0.268
	T2	17.857 (1.852)	19.571 (2.461)	18.413 (2.146)	3.518	5.923	0.034^*	0.052
	T3	19.095 (2.385)	19.619 (2.012)	18.522 (2.483)	1.638	4.889	0.200	0.087
Average shortest path length	T1	7.883 (0.690)	8.160 (0.780)	7.620 (0.637)	4.620	7.901	0.012^*	0.019^*
	T2	7.541 (0.648)	8.149 (0.893)	7.646 (0.571)	5.183	6.469	0.008^*	0.039^*
	T3	8.058 (0.857)	7.991 (0.703)	7.619 (0.675)	3.449	7.902	0.036^*	0.019^*
Tree hierarchy	T1	0.011 (0.001)	0.011 (0.001)	0.011 (0.001)	1.343	3.168	0.267	0.205
	T2	0.011 (0.001)	0.011 (0.001)	0.011 (0.001)	0.630	1.082	0.535	0.582
	T3	0.011 (0.001)	0.011 (0.001)	0.011 (0.001)	0.127	0.217	0.881	0.897
Leaf fraction	T1	0.450 (0.041)	0.418 (0.048)	0.454 (0.038)	5.795	8.639	0.004^*	0.013^*
	T2	0.451 (0.036)	0.427 (0.041)	0.449 (0.038)	2.883	4.743	0.061	0.093
	T3	0.449 (0.029)	0.427 (0.043)	0.444 (0.039)	2.024	3.370	0.139	0.186

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^* means statistically significant at 0.05 level; ANOVA is denoted as AOV