From:  T-cell based immunotherapies for Parkinson’s disease

Experimental T-cell-based immunotherapies tested in pre-clinical models of Parkinson’s disease

TreatmentEffect on T-cellsEffect on Parkinson’s diseaseModelReference
FK506Inhibits T-cell activationAttenuates motor impairment and neurodegenerationAAV-A53T-hαSyn in rat[22]
FTY720Arrest T-cells in lymph nodesAttenuates neuroinflammationAAV-hαSyn in mouse[17]
FTY720Arrest T-cells in lymph nodesAttenuates motor impairment, neuroinflammation and neurodegeneration6-OHDA in mouse[55]
FTY720Arrest T-cells in lymph nodesAttenuates motor impairment and neurodegeneration6-OHDA in mouse[56]
FTY720Arrest T-cells in lymph nodesAttenuates motor impairment and neurodegenerationRotenone in mouse[56]
FTY720Arrest T-cells in lymph nodesAttenuates motor impairment and neurodegenerationMPTP in mouse[57]
Rapamicyn + αSynIncreases Treg differentiationAttenuates neuroinflammation, neurodegeneration and synuclein pathologyTransgenic mice overexpressing hαSyn[58]
PNU-282987Increases Treg responseAttenuates motor impairment, neuroinflammation and neurodegeneration6-OHDA in rat[59]
VIPIncreases Treg number and activityAttenuates neuroinflammation and neurodegenerationMPTP in mouse[11]
VIP (LBT-3627)Increases Treg number and activityAttenuates neuroinflammation and neurodegenerationAAV-hαSyn in rat[64]
VIP (LBT-3627)Increases Treg number and activityAttenuates neuroinflammation and neurodegeneration6-OHDA in rat[64]
VIP (LBT-3627)Increases Treg number and activityAttenuates neuroinflammation and neurodegenerationMPTP in mouse[65]
GM-CSFFavours Treg generationAttenuates neuroinflammation and neurodegenerationMPTP in mouse[69]
GM-CSFFavours Treg generationAttenuates neuroinflammation and neurodegenerationAAV-hαSyn in rat[69]
PG01037Inhibits Th1/Th17 and increases Treg activityAttenuates motor impairment, neuroinflammation and neurodegenerationMPTP in mouse[75]
PG01037Inhibits Th1/Th17 and increases Treg activityAttenuates neurodegeneration6-OHDA in mouse[75]
Grp94 + αSynPromotes Treg and Th1 responseAttenuates neuroinflammationMPTP in mouse[76]
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