Exploration of Neuroprotective Therapy

Table 5

Final analytic model of psychiatric morbidity using Poisson regression (n = 705)

Variables within hierarchical models	IRR	SE	95% CI	P	Overall model statistics
Variables within hierarchical models	IRR	SE	95% CI	P	Pseudo R²	AIC	LR test
Base covariates				< 0.0001	0.061	2,560	Base
Age	0.98	0.002	0.98–0.99	< 0.001
Gender (ref. female)
Male	0.90	0.08	0.76–1.06	0.20
Transgender, non-binary, gender non-conforming, or other	0.97	0.15	0.71–1.32	0.86
Education (ref. ≤ HS)
Associate degree or some college	0.93	0.11	0.75–1.16	0.54
Bachelor’s degree	0.96	0.11	0.77–1.19	0.70
Master’s degree or above	0.93	0.11	0.75–1.17	0.54
MS subtype (ref. RRMS)
PPMS	1.27	0.16	0.99–1.62	0.06
SPMS	1.10	1.00	0.92–1.30	0.30
PRMS	1.34	0.27	0.91–1.98	0.14
Unsure	1.24	0.18	0.94–1.64	0.14
Pain med count	1.10	0.02	1.06–1.15	< 0.001
Childhood stressors				< 0.0001	0.090	2,485	< 0.0001
Child stressor count	0.97	0.05	0.88–1.07	0.57
Child stressor severity	1.02	0.01	1.00–1.04	0.11
Adult stressors				< 0.0001	0.116	2,420	< 0.0001
Adult stressor count	1.00	0.004	0.99–1.004	0.27
Adult stressor severity	1.01	0.002	1.006–1.014	< 0.0001

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≤ HS: high school equivalency or below; IRR: incident rate ratio; PPMS: primary progressive MS; PRMS: progressive-relapsing MS; ref.: reference; SPMS: secondary progressive MS. Blank cells indicate not applicable to individual variables