Exploration of Neuroprotective Therapy

Antiepileptic drug	Genetic polymorphisms	Implications	Reference(s)
Valproic acid	CYP2C93, CYP2A64	Influence on plasma concentrations may require dosage adjustments	[14]
Phenytoin	CYP2C92, CYP2C93, CYP2C192*	Reduced metabolism rate, unclear effects on CYP2C192, need for dosage adjustments. CYP2C19* mutations: Carriers may require reduced maintenance doses. CYP2C93: Associated with increased risk of severe cutaneous adverse reactions	[15–17]

Antiepileptic drug

Genetic polymorphisms

Implications

Reference(s)

Valproic acid

CYP2C93, CYP2A64

Influence on plasma concentrations may require dosage adjustments

[14]

Phenytoin

CYP2C92, CYP2C93, CYP2C19*2

Reduced metabolism rate, unclear effects on CYP2C19*2, need for dosage adjustments.
CYP2C19 mutations: Carriers may require reduced maintenance doses.
CYP2C93: Associated with increased risk of severe cutaneous adverse reactions

[15–17]