Genetic polymorphism and drug transporters
| Drug transporters | Genetic polymorphisms | Implications | Reference(s) |
|---|---|---|---|
| ABCB1 (P-glycoprotein) | 3435C>T | Associated with varying drug transportation activity, impacting drug response for carbamazepine and lamotrigine. Significant role in carbamazepine metabolism and resistance; T allele carriers show significantly different carbamazepine plasma levels. Influence on anticonvulsant drug efflux from brain tissue, potentially contributing to drug resistance; CC genotype associated with higher efflux. | [18–21] |
| EPHX1 | c.416A>G | Linked to carbamazepine metabolism, specifically conversion to carbamazepine-10,11-trans-dihydrodiol (CBZD). | [19] |