Lysophospholipid G protein-coupled receptors (GPCR). Nomenclature of the GPCRs and genes of S1P and LPA receptors as well as the G protein cell signaling pathways activated [2, 3]
| Ligand | GPCR (protein) | Gene nameMouse/human | Other names | Signaling pathways |
|---|---|---|---|---|
| S1P | S1P1 | S1pr1/S1PR1 | edg1, lpB1 | Gi/o |
| S1P2 | S1pr2/S1PR2 | edg5, lpB2, AGR16, H218 | Gi/o, Gq, G12/13 | |
| S1P3 | S1pr3/S1PR3 | edg3, lpB3 | Gi/o, Gq, G12/13 | |
| S1P4 | S1pr4/S1PR4 | edg6, lpC1 | Gi/o, G12/13, (Gs) | |
| S1P5 | S1pr5/S1PR5 | edg8, lpB4, Nrg-1 | Gi/o, G12/13, (Gs) | |
| LPA | LPA1 | Lpar1/LPAR1 | vzg1, edg2, lpA1 | Gi/o, Gq, G12/13 |
| LPA2 | Lpar2/LPAR2 | edg4, lpA2 | Gi/o, Gq, G12/13 | |
| LPA3 | Lpar3/LPAR3 | edg7, lpA3 | Gi/o, Gq | |
| LPA4 | Lpar4/LPAR4 | GPR23, p2y9 | Gs, Gq, G12/13 | |
| LPA5 | Lpar5/LPAR5 | GPR92 | Gq, G12/13 | |
| LPA6 | Lpar6/LPAR6 | p2y5 | Gs, G12/13 |
S1P4 and S1P5 primarily signal through Gi/o and G12/13, although there is some suggestion that they can signal through Gs (parentheses) under certain circumstances