Variable selection by hypothesized physiopathogenic mechanisms
| Physiopathogenic hypothesis | References | Hypothesis related variables | PCA selected | Higher weight | For cluster |
|---|---|---|---|---|---|
| DA hypoactivity in DLPC | [31, 32][35–42][96, 98] | TBR, zP300l, zP300azN200l, zN200azP50r, P100r | zP300l, zP300azN200a, zP50r | P300l | 1 |
| Perisylvian network hyperexcitability | [55, 66–71, 102] | zWBP, CTS | zWBP, CTS | zWBP, CTS | 2 |
| Excite-inhibit imbalance, thalamocortical | [48, 102] | zTBR, BSSW | BSSW | BSSW | 3 |
| Misallocation of attentional resources | [35, 41] | zP300l, zP300a, zN200l, zN200a, zP50r, P100r, zFBP | zP300l, zP300a, zN200a, zP50r, zFBP | zP300a, zP50r, zFBPP | 4 |
| Vascular-metabolic decoupling, Cx hyperexcitability | [95, 98] | zDP, zFBP, HR, SST | zFBP, HR, SST | zFBP, HR, SST | 5 |
| Poor interhemispheric collaboration | [82, 105] | zMA | zMA | zMA | 6 |
On the first and second column, physiopathogenic hypothesis and bibliographic references, followed by the EEG/ERP variables associated with other disorders and supporting references (after PCA selection); fourth column, variables statistically selected as independent contributors to the variance; in the fifth, variables with highest loads to a specific cluster; and the cluster number in the last column. DA: dopamine; PFC: prefrontal cortex; ThCx: thalamocortical; TBR: theta-beta ratio; zP300l: z-scored auditory P300 latency; zP300a: z-scored auditory P300 amplitude; zP50r: z-scored auditory P50 ratio; zWBP: z-scored Wide-Band Power (focal); zFBP: z-scored fast beta power (26–29 Hz sub-band, regional); zHR: z-scored 20 Hz power during 20 Hz photic stimulation; CTS: centrotemporal spikes; SST: small sharp transients; BSSW: bisynchronous spike waves; zMA: z-scored maturational asymmetry; PCA: Principal Component Analysis