Regional AmyvidTM binding ratios (with cerebellum as reference region) at baseline and FU for the treatment and placebo group
| Treatment | Placebo | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline AmyvidTM | Participant No. | 1 | 3 | 6 | 8 | 9 | 10 | Participant No. | 2 | 4 | 5 | 7 | ||||
| Regions | Mean | SD | Regions | Mean | SD | |||||||||||
| Frontal lobe | 1.794 | 2.316 | 1.832 | 2.146 | 1.778 | 2.057 | 1.987 | 0.221 | Frontal lobe | 1.623 | 2.056 | 1.759 | 1.810 | 1.812 | 0.181 | |
| Parietal lobe | 1.822 | 2.300 | 1.703 | 2.015 | 1.756 | 2.080 | 1.946 | 0.227 | Parietal lobe | 1.503 | 1.938 | 1.810 | 1.735 | 1.747 | 0.183 | |
| Temporal lobe | 1.444 | 1.970 | 1.679 | 1.644 | 1.551 | 1.737 | 1.671 | 0.179 | Temporal lobe | 1.373 | 1.630 | 1.527 | 1.562 | 1.523 | 0.109 | |
| Occipital lobe | 1.291 | 1.869 | 1.885 | 1.445 | 1.511 | 1.510 | 1.585 | 0.240 | Occipital lobe | 1.252 | 1.536 | 1.546 | 1.531 | 1.466 | 0.143 | |
| Insula | 1.585 | 2.091 | 1.751 | 1.855 | 1.679 | 1.751 | 1.785 | 0.174 | Insula | 1.414 | 1.785 | 1.551 | 1.724 | 1.619 | 0.169 | |
| Anterior cingulate | 1.828 | 2.539 | 1.961 | 2.190 | 1.906 | 2.224 | 2.108 | 0.263 | Anterior cingulate | 1.774 | 2.299 | 2.019 | 2.053 | 2.036 | 0.215 | |
| Posterior cingulate | 2.008 | 2.667 | 1.863 | 2.262 | 2.133 | 2.327 | 2.210 | 0.280 | Posterior cingulate | 1.654 | 2.207 | 2.185 | 2.041 | 2.022 | 0.256 | |
| Thalamus | 1.031 | 1.701 | 0.921 | 1.357 | 1.368 | 1.317 | 1.282 | 0.277 | Thalamus | 1.132 | 1.335 | 1.251 | 1.236 | 1.238 | 0.083 | |
| Cerebellum | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 0.000 | Cerebellum | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 0.000 | |
| Brainstem | 1.225 | 1.516 | 1.107 | 1.380 | 1.298 | 1.212 | 1.290 | 0.144 | Brainstem | 1.093 | 1.342 | 1.250 | 1.418 | 1.276 | 0.140 | |
| Global mean | 1.517 | 1.918 | 1.614 | 1.701 | 1.548 | 1.714 | 1.669 | 0.145 | Global mean | 1.385 | 1.667 | 1.558 | 1.575 | 1.546 | 0.118 | |
| FU AmyvidTM | Participant No. | 1 | 3 | 6 | 8 | 9 | 10 | Participant No. | 2 | 4 | 5 | 7 | ||||
| Regions | Mean | SD | Regions | Mean | SD | |||||||||||
| Frontal lobe | no FU | 2.374 | 1.638 | 2.009 | 1.961 | 1.973 | 1.991 | 0.261 | Frontal lobe | 1.713 | 2.024 | 1.851 | 1.592 | 1.795 | 0.186 | |
| Parietal lobe | no FU | 2.309 | 1.590 | 1.916 | 1.909 | 1.947 | 1.934 | 0.255 | Parietal lobe | 1.580 | 1.913 | 1.913 | 1.515 | 1.730 | 0.212 | |
| Temporal lobe | no FU | 1.907 | 1.558 | 1.547 | 1.691 | 1.644 | 1.670 | 0.146 | Temporal lobe | 1.419 | 1.571 | 1.589 | 1.372 | 1.488 | 0.109 | |
| Occipital lobe | no FU | 1.819 | 1.760 | 1.402 | 1.641 | 1.455 | 1.615 | 0.183 | Occipital lobe | 1.282 | 1.479 | 1.545 | 1.329 | 1.409 | 0.124 | |
| Insula | no FU | 2.056 | 1.582 | 1.729 | 1.853 | 1.656 | 1.775 | 0.186 | Insula | 1.514 | 1.720 | 1.669 | 1.425 | 1.582 | 0.136 | |
| Anterior cingulate | no FU | 2.509 | 1.756 | 2.105 | 2.081 | 2.127 | 2.116 | 0.267 | Anterior cingulate | 1.824 | 2.134 | 2.036 | 1.781 | 1.944 | 0.169 | |
| Posterior cingulate | no FU | 2.649 | 1.798 | 2.150 | 2.329 | 2.010 | 2.187 | 0.323 | Posterior cingulate | 1.700 | 2.097 | 2.373 | 1.686 | 1.964 | 0.333 | |
| Thalamus | no FU | 1.393 | 0.885 | 1.320 | 1.517 | 1.228 | 1.269 | 0.239 | Thalamus | 1.189 | 1.243 | 1.352 | 1.123 | 1.227 | 0.097 | |
| Cerebellum | no FU | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 0.000 | Cerebellum | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 0.000 | |
| Brainstem | no FU | 1.417 | 1.118 | 1.322 | 1.353 | 1.098 | 1.261 | 0.145 | Brainstem | 1.122 | 1.375 | 1.408 | 1.217 | 1.280 | 0.135 | |
| Global mean | 1.911 | 1.496 | 1.618 | 1.675 | 1.630 | 1.666 | 0.152 | Global mean | 1.440 | 1.625 | 1.616 | 1.396 | 1.519 | 0.118 | ||