Studies utilizing unmodified EVs on PD models
| Therapeutic cargo | EV source | Experiment type | Ref. |
|---|---|---|---|
| Natural EV-cargo | SHEDs | In vitro | [74] |
| Natural EV-cargo | SHEDs | In vivo | [75] |
| Natural EV-cargo | hUC-MSCs | In vitro and in vivo | [71] |
| Natural EV-cargo but rich in miRNA-106b | hUC-MSCs | In vitro and in vivo | [70] |
| Natural EV-cargo but rich in Wnt5 | BM-MSCs and BM-MSC-derived DA neuron | In vivo | [77] |
| Natural EV-cargo | BM-MSCs | In vivo | [79] |
| Natural EV-cargo but rich in Wnt5 | BM-MSCs and BM-MSC-derived DA neuron | In vivo | [78] |
| Natural EV-cargo | hUC-MSCs | In vitro and in vivo | [76] |
The authors acknowledge Servier Medical Art (https://smart.servier.com) and BioIcons (https://bioicons.com) for providing the icons used for the images. Icons were developed by Servier and DBCLS and licensed under Creative Commons Attribution 3.0 Unported License and Creative Commons Attribution 4.0 International License, respectively.
MRT and ALA equally contributed to: Conceptualization, Writing—original draft, Visualization. VRdC and JRDP: Writing—original draft. RPA: Supervision, Writing—review & editing.
The authors declare that they have no conflicts of interest.
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© The Author(s) 2023.