Major findings of the preclinical evidences of Cuban policosanol on stroke
| Author | Year | Animal model | Dosing mode | Major findings |
|---|---|---|---|---|
| Arruzazabala et al. [33] | 1993 | Permanent ligature of a carotid in Mongolian gerbils | Preventive single oral doses (25 mg/kg, 50 mg/kg, and 200 mg/kg) | Cuban policosanol reduced clinical symptoms and mortality, associated to a TxA2 reduction and PgI2 increase |
| Preventive single oral doses of policosanol (25 mg/kg) plus aspirin (30 mg/kg) | This combination was more effective than the respective monotherapies on clinical symptoms and mortality, showing a synergism between them | |||
| Molina et al. [35] | 1999 | Permanent ligature of a carotid in Mongolian gerbils | Therapeutic single oral doses (100 mg/kg and 200 mg/kg) | Cuban policosanol (200 mg/kg) reduced clinical symptoms and mortality; and also it protected against brain histological damage |
| Bilateral ischemia and reperfusion in Mongolian gerbils | Therapeutic single oral doses (200 mg/kg) | Cuban policosanol reduced edema and restored AMPc levels in cerebral tissue | ||
| Molina et al. [40] | 2013 | Bilateral ischemia and reperfusion in Mongolian gerbils | Preventive single oral doses of Cuban policosanol and GSE (100 mg/kg and 200 mg/kg) | Both treatments inhibited similarly the hyper-locomotion, brain histological damage and plasma oxidative markers |
| Molina et al. [43] | 2015 | Bilateral ischemia and reperfusion in Mongolian gerbils | Preventive oral doses of Cuban policosanol (100 mg/kg and 200 mg/kg) and omega-3 fish oil (1.25 g/kg and 2.5 g/kg) during 4 weeks | Both treatments prevented global cerebral ischemia with similar efficacy on hyper-locomotion and plasma oxidative markers, but being policosanol more effective on histological damage score |
| Molina et al. [44] | 2017 | Bilateral ischemia and reperfusion in Mongolian gerbils | Therapeutic oral doses of Cuban policosanol (100 mg/kg and 200 mg/kg) and omega-3 fish oil (1.25 g/kg and 2.5 g/kg) during 7 days | Both treatments reduced global cerebral ischemia with similar efficacy on neurological symptoms score and plasma oxidative markers, but being policosanol more effective on brain histological damage score |
| Molina et al. [45] | 2013 | Bilateral ischemia and reperfusion in Mongolian gerbils | Therapeutic single oral doses of Cuban policosanol (100 mg/kg and 200 mg/kg) and atorvastatin (10 mg/kg and 20 mg/kg) | Both treatments reduced global cerebral ischemia with similar efficacy on neurological symptoms score, hyper-locomotion and brain histological damage score. Cuban policosanol produced antioxidant effects, unlike atorvastatin that did not modify it |
| Molina et al. [46] | 2018 | Bilateral ischemia and reperfusion in Mongolian gerbils | Single therapeutic doses of Cuban policosanol (100 mg/kg) plus aspirin (60 mg/kg), Cuban policosanol (100 mg/kg) plus atorvastatin (20 mg/kg) and aspirin (60 mg/kg) | Both combinations reduced similarly clinical symptoms, hyper-locomotion and histological damage, but with a major efficacy respect to aspirin monotherapy |