From:  Brain metastasis from the perspective of molecular mechanisms and treatment, presenting a new approach for targeting ion channels by nano drugs

Treatment by targeting molecular mechanisms

MedicineCancerMolecular mechanism target
PembrolizumabCNS metastases from NSCLCPD-1
LapatinibHER2+ breast cancerTKI activity associated with EGFR and HER2
Combination of lapatinib and capecitabineBrain metastases

TKI activity associated with EGFR and HER2, inhibiting the synthesis of thymidine monophosphate

Afatinib, crizotinib, gefitinib, and erlotinibLung cancer and brain metastasisALK inhibitors
Osimertinib and ceritinibLung cancer and brain metastasisTyrosine kinase
Dabrafenib and vemurafenibMetastatic melanoma BRAF inhibitors
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