Main outcomes
| Outcome measure | RD | BM | P-value |
|---|---|---|---|
| Therapeutic success (stops seizure < 10 min, for 1 hour, without respiratory depression) | 7/12 | 7/12 | |
| Time from onset to administration (min) | 6.0 (5–30) | 6.0 (5–30) | |
| Time from administration to seizure cessation (min) | 7.0 (3–13) | 7.5 (1.5–13.5) | |
| Sedation | 8/12 | 10/12 | |
| Respiratory depression | None | None | |
| Ease of administration | 7/12 | 9/12 | |
| Ultimate parental preference | 1/12 | 9/12 | P < 0.05 |
McNemar’s test, Wilcoxon matched-pairs signed-ranks test, and Chi-squared test were applied as appropriate. Ease of administration was recorded by parents as either “easy to give” or not. Blank cells indicate no statistically significant difference. RD: rectal diazepam; BM: buccal midazolam