Exploration of Neuroscience

Table 1

Summary of preclinical studies that describe S1R KO or antagonists in different NP models

Pain type	Pain model	Specie	Sex	Ligand	Route	Effect on pain	References
Central neuropathic pain	Spinal cord contusion	Mouse	F	E-52862	i.p. 7 days	↓ mechanical allodynia and thermal hyperalgesia	[98]
		Mouse	F	E-52862	i.p.	↓ mechanical allodynia and thermal hyperalgesia	[100]
		Mouse	F	KO		No mechanical allodynia and thermal hyperalgesia	[100]
Peripheral neuropathic pain	Streptozotocin-induced	Rat	M	E-52862	i.p., acute, b.i.d. 7 days	↓ mechanical hyperalgesia	[97]
		Rat	M	PW507	i.p., acute, b.i.d. 14 days	↓ mechanical allodynia and thermal hyperalgesia	[111]
		Mouse	M	BD-1047	i.t. 7 days	↓ mechanical allodynia and thermal hyperalgesia	[112]
	Nicotinamide-streptozotocin induced	Mouse	M	Haloperidol	s.c.	↓ mechanical allodynia and hyperalgesia	[113]
	Nicotinamide-streptozotocin induced	Mouse	M	LMH-2	s.c.	↓ mechanical allodynia and hyperalgesia	[113]
	Zucker diabetic fatty	Rat	M	E-52862	i.p., acute, b.i.d. 14 days	↓ mechanical allodynia and thermal hyperalgesia	[114]
	High-fat diet	Mouse	M	KO		No mechanical allodynia and thermal hyperalgesia	[115]
	High-fat diet	Mouse	M	BD-1047	i.t.	↓ mechanical allodynia and thermal hyperalgesia	[115]
	Oxaliplatin-induced	Rat	M	E-52862	i.p., acute, b.i.d. 7 days	↓ cold allodynia	[97]
	Cisplatin-induced	Mouse	M	CM304	i.p.	↓ mechanical allodynia	[116]
	Paclitaxel-induced	Mouse	F	E-52862	s.c.	↓ mechanical allodynia and cold hyperalgesia	[101]
		Mouse	F	BD-1047	s.c.	↓ mechanical allodynia and cold hyperalgesia	[101]
		Mouse	F	KO		No mechanical allodynia and cold hyperalgesia	[101]
		Rat	M	PW507	i.p.	↓ cold hyperalgesia	[103]
	Partial sciatic nerve ligation	Mouse	M	E-52862	i.p., acute, b.i.d. 21 days	↓ mechanical allodynia and thermal hyperalgesia	[104]
		Mouse	M	E-52862	i.v.10 days	↓ mechanical allodynia and thermal hyperalgesia	[105]
		Mouse	M	KO		No mechanical allodynia and thermal hyperalgesia	[102]
	Chronic constriction injury	Rat	M	BD-1047	i.t.	↓ mechanical allodynia	[106]
		Rat	M	BD-1047	p.o.	↓ mechanical allodynia and cold hyperalgesia	[107]
		Mouse	M	BD-1047	i.t.	↓ mechanical allodynia	[108]
		Rat	M	E-52862	i.p., acute, b.i.d. 7 days	↓ mechanical allodynia	[97]
		Mouse	M	CM304	i.p.	↓ mechanical allodynia	[116]

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i.p.: intraperitoneal; i.pl.: intraplantar; i.t.: intrathecal; i.v.: intravenous; p.o.: oral; s.c.: subcutaneous; b.i.d.: twice daily; KO: knockout