Molecular targets, pathways, effects on glioma cells, and potential therapeutic agents
| Molecular target | Pathway | Effect on glioma cells | Potential therapeutic agents | Reference |
|---|---|---|---|---|
| TSPO | Mitochondrial function | Promotes cell survival, reduces apoptosis | TSPO ligands (e.g., [11C]PK11195) | [115] |
| NF-κB | Inflammation | Enhanced by cytokine release | NF-κB inhibitors | [116] |
| ROS | Oxidation stress | Increases oxidative damage and proliferation | Antioxidants (e.g., N-acetylcysteine) | [117] |
| Cytochrome C | Apoptotic pathways | Reduced release lowers apoptosis | TSPO inhibitors | [118] |
[11C]PK11195: [11C]N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cell; ROS: reactive oxygen species; TSPO: translocator protein