The numbers of transmembrane-electrostatically localized protons/cations charges (TELC) per μm2 of membrane surface area or per cell computed from the resting membrane potential, stimulation threshold, and action potential peak level in a typical ellipsoidal Neuro2A (N2A) cell with a cell volume of 2,700 μm3 and extracellular membrane surface area of about 1,000 μm2, using specific membrane capacitance C/S of 9.2 mf/m2 based on measured experimental data [37]
Neural membrane potential | TELC per μm2 on extracellular membrane surface | TELC per μm2 on cytoplasmic membrane surface | TELC per cell on extracellular membrane surface | TELC per cell on cytoplasmic membrane surface | |
---|---|---|---|---|---|
Resting potential level | –70 mV | 3,900 excess protons + cations | 3,900 excess anions | 3,900,000 excess protons + cations | 3,900,000 excess anions |
Stimulation threshold level | –55 mV | 3,100 excess protons + cations | 3,100 excess anions | 3,100,000 excess protons + cations | 3,100,000 excess anions |
Action potential peak level | +30 mV | 1,700 excess anions | 1,700 excess protons + cations | 1,700,000 excess anions | 1,700,000 excess protons + cations |