Assessment of SAD by combining 3 or more parameters within the 3 diagnostic groups (based on at least 3 SAdf > 1.645 SDS)
| Number of parameters [n (%)] | Asthma [n = 81 (16.2%)] | ACO [n = 113 (22.6%)] | COPD [n = 305 (61.1%)] | All SAD [n = 499 (100%)] | |
|---|---|---|---|---|---|
| 3 | f | 12 (14.8) | 14 (12.4) | 10 (3.3) | 36 (7.2) |
| 4 | g | 50 (61.7) | 39 (34.5) | 80 (26.2) | 169 (33.9) |
| 5 | h | 17 (21.0) | 31 (27.4) | 78 (25.6) | 126 (25.3) |
| 6 | i | 2 (2.5) | 29 (25.7) | 137 (44.9) | 168 (33.7) |
SDS: SD score
The authors are grateful to the staff of all study centers, especially to the study nurses for their excellent and enduring work in data collection, and the authors thank Prof. Sabina Gallati from Human Genetics of Hirslanden Precise, Zürich, for the critical reviews of the manuscript.
RK: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. HM: Writing—review & editing. Both authors read and approved the submitted version.
The authors declare that they have no conflicts of interest.
The study was planned according to the Federal Law of Human Research, conceptualized according to the Swiss Ethics Committees on research involving humans, and was conducted in accordance with the tenets of the Declaration of Helsinki. The study is part of the framework of the project entitled “Functional diversification of the Asthma-ACO-COPD multi-center study” (ID 2017-00259), approved by the Governmental Ethics Committees of the State of Bern, St. Gallen, Solothurn, and Zürich (project KEK-BE PB_2017-00104).
All 4 Ethics Committees exempted the informed consent to participate since the data were retrospectively evaluated and anonymous.
Not applicable.
Master-files have been stored and secured in the Clinical Trial Unit (CTU), Hirslanden, Corporate Office, CH-8152 Glattpark, Switzerland, and are available upon request from the corresponding author (richard.kraemer@hirslanden.ch) or the office manager, Mr. Daniel Tschopp, Head Clinical Trial Unit, Hirslanden (ClinicalTrialUnit.Hirslanden@hirslanden.ch).
Not applicable.
© The Author(s) 2024.