Exploration of Asthma & Allergy

Botanical family (plant foods)	Allergen source
Compositae	Roman chamomile Pyrethrum Chicory
Brassicaceae	Rocket
Others	Potato Carrot Leek Melon Cereals Legumes

Declarations

Author contributions

KA and NN: Conceptualization. KA: Writing—original draft. KA, EM, AP, and NN: Writing—review & editing. NN: Investigation, Supervision. All authors contributed to the manuscript revision, and read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study was approved by the Cyprus National Bioethics Committee EEBK 21.1.01.03.

Consent to participate

Informed consent to participate in the study was obtained from the patient.

Consent to publication

Informed consent to publication was obtained from the relevant patient.

Availability of data and materials

The anonymized medical notes and test results could be provided upon request from the Asthma and Allergy Center (Nicolaos Nicolaou, nic.nicolaou@googlemail.com).

Funding

Not applicable.

Copyright

References

Aruanno A, Urbani S, Frati F, Nucera E. LTP allergy/sensitization in a pediatric population. Allergol Immunopathol (Madr). 2020;48:763–70. [DOI] [PubMed]

Paulsen E. Systemic allergic dermatitis caused by sesquiterpene lactones. Contact Dermatitis. 2017;76:1–10. [DOI] [PubMed]

Vila L, Sánchez G, Sanz ML, Diéguez I, Martínez A, Palacios R, et al. Study of a case of hypersensitivity to lettuce (Lactuca sativa). Clin Exp Allergy. 1998;28:1031–5. [DOI] [PubMed]

Helbling A, Schwartz HJ, Lopez M, Lehrer SB. Lettuce and carrot allergy: are they related? Allergy Proc. 1994;15:33–8. [DOI] [PubMed]

Garcia Ortiz JC, Cosmes PM, Lopez-Asunsolo A. Allergy to foods in patients monosensitized to Artemisia pollen. Allergy. 1996;51:927–31. [DOI] [PubMed]

Escudero A, Bartolomé B, Sánchez-Guerrero IM, Palacios R. Lettuce and chicory sensitization. Allergy. 1999;54:183–4. [PubMed]

Franck P, Kanny G, Dousset B, Nabet P, Moneret-Vautrin DA. Lettuce allergy. Allergy. 2000;55:201–2. [DOI] [PubMed]

Muñoz-García E, Luengo-Sánchez O, Moreno-Pérez N, Cuesta-Herranz J, Pastor-Vargas C, Cardona V. Lettuce allergy is a lipid transfer syndrome-related food allergy with a high risk of severe reactions. J Investig Allergol Clin Immunol. 2017;27:98–103. [DOI] [PubMed]

Pascal M, Muñoz-Cano R, Reina Z, Palacín A, Vilella R, Picado C, et al. Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. Clin Exp Allergy. 2012;42:1529–39. [DOI] [PubMed]

10.

Paulsen E, Sommerlund M, Andersen F. Contact sensitization to lettuce and rocket-salad with and without systemic elicitation of dermatitis after oral challenge. Contact Dermatitis. 2014;71:188–90. [DOI] [PubMed]

11.

Salcedo G, Sanchez-Monge R, Diaz-Perales A, Garcia-Casado G, Barber D. Plant non-specific lipid transfer proteins as food and pollen allergens. Clin Exp Allergy. 2004;34:1336–41. [DOI] [PubMed]

12.

Pastorello EA, Robino AM. Clinical role of lipid transfer proteins in food allergy. Mol Nutr Food Res. 2004;48:356–62. [DOI] [PubMed]

13.

Hartz C, del Mar San Miguel-Moncín M, Cisteró-Bahíma A, Fötisch K, Metzner KJ, Fortunato D, et al. Molecular characterisation of Lac s 1, the major allergen from lettuce (Lactuca sativa). Mol Immunol. 2007;44:2820–30. [DOI] [PubMed]

14.

Muñoz-García E, Luengo-Sánchez O, Haroun-Díaz E, Maroto AS, Palacín A, Díaz-Perales A, et al. Identification of thaumatin-like protein and aspartyl protease as new major allergens in lettuce (Lactuca sativa). Mol Nutr Food Res. 2013;57:2245–52. [DOI] [PubMed]

15.

Bascones O, Rodríguez-Pérez R, Juste S, Moneo I, Caballero ML. Lettuce-induced anaphylaxis. Identification of the allergen involved. J Investig Allergol Clin Immunol. 2009;19:154–7. [PubMed]

16.

San Miguel-Moncín M, Krail M, Scheurer S, Enrique E, Alonso R, Conti A, et al. Lettuce anaphylaxis: identification of a lipid transfer protein as the major allergen. Allergy. 2003;58:511–7. [DOI] [PubMed]

17.

Lamnisos D, Giannakou K, Jakovljevic MM. Demographic forecasting of population aging in Greece and Cyprus: one big challenge for the Mediterranean health and social system long-term sustainability. Health Res Policy Syst. 2021;19:21.

18.

Krook G. Simultaneous occurrence of immediate and delayed allergy as a cause of contact dermatitis. Contact Derm. 1977;3:27–36.

19.

Aalberse RC, Acevedo N, Aglas L, Altmann F, Arruda KL, Asero R, et al. Molecular allergology user’s guide 2.0. Hoffmann-Sommergruber K, Hilger C, Santos A, de las Vecillas L, Dramburg Seditors. Switzerland: EAACI; 2022.