Clinical characteristics of the study patients at referral to the Pediatric Asthma Center
| Individual data | Case 1 | Case 2 | Case 3 | Case 4 |
|---|---|---|---|---|
| Age at asthma onset | 3 months | 12 years | 3 years | 10 months |
| Allergic sensitization | House dust mites, cat dander, Olea Europaea, Alternaria alternata | Grass pollen, Artemisia, Olea europaea, Parietaria judaica | House dust mites, cat dander, Olea europaea, Parietaria judaica | House dust mites, cat/dog dander, Alternaria alternata, Grass pollen |
| Symptoms burden | Cough, exercise-induced dyspnea, frequent asthma attacks | Daily chest tightness, cough, exercise-induced dyspnea | Weekly cough, dyspnea, and night awakenings | Daily cough, exercise-induced dyspnea, frequent asthma attacks |
| T2-related comorbidity | No | Nasal polyposis | No | Atopic dermatitis, allergic rhinitis |
| NonT2-related comorbidity | No | No | Obesity and insulin resistance | No |
| Treatment | Flu/Sal + LTRA | Bud/Form + LTRA | Bud/Form | Flu + LTRA |
| Age at start of biologic | 13 years | 16 years | 14 years | 9 years |
| Asthma attacks/year | 7 | 5 | 6 | 7 |
Flu/Sal: fluticasone propionate/salmeterol; LTRA: leukotriene receptor antagonist; Bud/Form: budesonide/formoterol