Exploration of Asthma & Allergy

Table 1. Eosinophils and mast cells in diseases

Disease	Eosinophils	Mast cells
allergic conjunctivitis	Yes	Yes
allergic inflammation	Yes	Yes
allergic/contact dermatitis	Yes	Yes
allergic cutaneous vasculitis (hypersensitivity vasculitis/cutaneous small vessel vasculitis)	Yes	Yes
allergy	Yes	Yes
anaphylaxis	Yes	Yes
asthma	Yes	Yes
atopic dermatitis (AD) (eczema)	Yes	Yes
chronic heart failure (CHF)	Some	Some
cutaneous necrotizing venulitis	Yes	Yes
eosinophilic asthma	Yes	Yes
eosinophilic gastrointestinal disorders (EGIDs)	Yes	Yes
eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss syndrome)	Yes	Yes
eosinophilic pancreatitis (EP)	Yes	Yes
EGID: eosinophilic colitis (EC)	Yes	Yes
EGID: eosinophilic esophagitis (EoE)	Yes	Yes
EGID: eosinophilic gastroenteritis (EGE)/eosinophilic enteritis (EE)	Yes	Proposed
functional gastrointestinal disorders (FGIDs)	Yes	Yes
hypereosinophilic syndrome (HES)	Yes	Yes
Kimura’s disease	Yes	Significantly increased; possible role
Kounis syndrome (KS)	Yes	Yes
mast cell activation syndrome (MCAS)	Elevated; complex relationship	Yes
mastocytosis	Yes	Yes
rheumatoid arthritis (RA)	Yes	Yes
systemic mastocytosis with eosinophilia (SMCD-eos)	Yes	Yes

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Declarations

Acknowledgments

The author acknowledges Dr. Nicole Gherlone and Dr. Maurice Fremont-Smith for useful conversations.

Author contributions

DOR: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. The author has read and approved the submitted version.

Conflicts of interest

The author declares that he has no conflicts of interest.

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