Exploration of Cardiology

Table 1. Definitions of electrocardiographic indicators of LVH used in the study

The SLI	CV	CP
S_V1 + R_V5/V6 > 3.5 mV [28]	R_aVL + S_V3 > 2.8 mV (men) R_aVL + S_V3 > 2.0 mV (women) [29]	(R_aVL + S_V3) × QRS width ≥ 2,440 mm × ms [30]

The SLI

S_V1 + R_V5/V6 > 3.5 mV [28]

R_aVL + S_V3 > 2.8 mV (men)

R_aVL + S_V3 > 2.0 mV (women) [29]

(R_aVL + S_V3) × QRS width ≥ 2,440 mm × ms

aVL: left arm lead of ECG; QRS: an electrocardiographic complex consisting of the Q, R, and S waves; V1, V3, V5, V6: respective precordial leads of ECG

Declarations

Author contributions

BN, KWD, and ET: Methodology. BN, AG, and RN: Investigation. RN, BN, TR, ET, MK, PL, JDK, and KWD: Formal analysis. BN, RN, AG, TR, ET, MK, PL, JDK, and KWD: Writing—original draft.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This manuscript complies with the Declaration of Helsinki. The research was conducted with the approval of the Bioethics Committee of the Medical University of Lodz number RNN/31/16/KE.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Informed consent to publication was obtained from all participants.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

References

Zdrojewski T, Rutkowski M, Bandosz P, Gaciong Z, Jędrzejczyk T, Solnica B, et al. Prevalence and control of cardiovascular risk factors in Poland. Assumptions and objectives of the NATPOL 2011 Survey. Kardiol Pol. 2013;71:381–92. [DOI] [PubMed]

Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34:2159–219. [DOI] [PubMed]

Kannel WB, Cobb J. Left ventricular hypertrophy and mortality – results from Framingham Study. Cardiology. 1992;81:291–8. [DOI] [PubMed]

Możdżan M, Wierzbowska-Drabik K, Kurpesa M, Trzos E, Rechciński T, Broncel M, et al. Echocardiographic indices of left ventricular hypertrophy and diastolic function in hypertensive patients with preserved LVEF classified as dippers and non-dippers. Arch Med Sci. 2013;9:268–75. [DOI] [PubMed] [PMC]

Antikainen R, Grodzicki T, Palmer AJ, Beevers DG, Coles EC, Webster J, et al. The determinants of left ventricular hypertrophy defined by Sokolow-Lyon criteria in untreated hypertensive patients. J Hum Hypertens. 2003;17:159–64. [DOI] [PubMed]

Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013;62:263–71. [DOI] [PubMed]

Liu Q, Chen HB, Luo M, Zheng H. Serum soluble RAGE level inversely correlates with left ventricular hypertrophy in essential hypertension patients. Genet Mol Res. 2016;15. [DOI] [PubMed]

Donato M, Buchholz B, Morales C, Valdez L, Zaobornyj T, Baratta S, et al. Loss of dystrophin is associated with increased myocardial stiffness in a model of left ventricular hypertrophy. Mol Cell Biochem. 2017;432:169–78. [DOI] [PubMed]

Blume GG, McLeod CJ, Barnes ME, Seward JB, Pellikka PA, Bastiansen PM, et al. Left atrial function: physiology, assessment, and clinical implications. Eur J Echocardiogr. 2011;12:421–30. [DOI] [PubMed]

10.

Zdrojewski T. Częstość występowania i świadomość nadciśnienia tętniczego w Polsce i na świecie. Postępy Nauk Medycznych. 2011;3:4–10. Polish.

11.

Fojt T, Kurek A, Szewieczek J, Janowska M, Duława J. Left ventricular hypertrophy in patients over the age of 75 suffering from hypertension, diabetes mellitus and renal failure. Ann Acad Med Siles. 2013;67:91–9.

12.

Szymański L, Mandecki T, Twardowski R, Mizia-Stec K, Szulc A, Jastrzębska-Maj E. QT dispersion and characteristics of left ventricular hypertrophy in primary hypertension. Pol Arch Med Wewn. 2002;107:19–27. [PubMed]

13.

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:937–52. [DOI] [PubMed]

14.

Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Gattobigio R, Zampi I, et al. Prognostic of new electrocardiographic method for diagnosis of left ventricular hypertrophy in essential hypertension. J Am Coll Cardiol. 1998;31:383–90. [DOI] [PubMed]

15.

Vakili BA, Okin PM, Devereux RB. Prognostic implications of left ventricular hypertrophy. Am Heart J. 2001;141:334–41. [DOI] [PubMed]

16.

Kurpesa M. P Przerost mięśnia sercowego w zapisie EKG – nie tylko wysokie załamki R. Kardiologia po Dyplomie. 2009;10:52–5. Polish.

17.

Roszczyk N, Wierzbowska-Drabik K, Kasprzak JD. Assessment of left atrial size and function. Kardiol Pol. 2012;70:1046–52. [PubMed]

18.

Oseni AO, Qureshi WT, Almahmoud MF, Bertoni AG, Bluemke DA, Hundley WG, et al. Left ventricular hypertrophy by ECG versus cardiac MRI as a predictor for heart failure. Heart. 2017;103:49–54. [DOI] [PubMed] [PMC]

19.

Cuspidi C, Facchetti R, Sala C, Bombelli M, Tadic M, Grassi G, et al. Do combined electrocardiographic and echocardiographic markers of left ventricular hypertrophy improve cardiovascular risk estimation? J Clin Hypertens (Greenwich). 2016;18:846–54. [DOI] [PubMed] [PMC]

20.

Bacharova L, Estes HE, Schocken DD, Ugander M, Soliman EZ, Hill JA, et al. The 4th report of the working group on ECG diagnosis of left ventricular hypertrophy. J Electrocardiol. 2017;50:11–5. [DOI] [PubMed]

21.

Oreto G, Saporito F, Messina F, Lanteri S, Luzza F. Electrocardiographic diagnosis of left ventricular hypertrophy in the presence of intraventricular conduction disturbances. G Ital Cardiol (Rome). 2007;8:161–7. Italian. [PubMed]

22.

Pewsner D, Jüni P, Egger M, Battaglia M, Sundström J, Bachmann LM. Accuracy of electrocardiography in the diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. BMJ. 2007;335:711. [DOI] [PubMed] [PMC]

23.

Rautaharju PM, Soliman EZ. Electrocardiographic left ventricular hypertrophy and the risk of adverse cardiovascular events: a critical appraisal. J Electrocardiol. 2014;47:649–54. [DOI] [PubMed]

24.

Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450–8. [DOI] [PubMed]

25.

Wierzbowska-Drabik K, Krzemińska-Pakuła M, Drożdż J, Plewka M, Trzos E, Kurpesa M, et al. Enlarged left atrium is a simple and strong predictor of poor prognosis in patients after myocardial infarction. Echocardiography. 2008;25:27–35. [DOI] [PubMed]

26.

To ACY. Flamm SD, Marwick TH, Klein AL. Clinical utility of multimodality LA imaging: assessment of size, function, and structure. JACC Cardiovasc Imaging. 2011;4:788–98. [DOI] [PubMed]

27.

Hoit BD. Left atrial size and function: role in prognosis. J Am Coll Cardiol. 2014;63:493–505. [DOI] [PubMed]

28.

Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limbs leads. Am Heart J. 1949;37:161–86. [DOI]

29.

Casale PN, Devereux RB, Kligfield P, Eisenberg RR, Miller DH, Chaudhary BS, et al. Electrocardiographic detection of left ventricular hypertrophy: Development and prospective validation of improved criteria. J Am Coll Cardiol. 1985;6:572–80. [DOI] [PubMed]

30.

Ishikawa J, Ishikawa S, Kabutoya T, Gotoh T, Kayaba K, Schwartz JE, et al. Cornell product left ventricular hypertrophy in electrocardiogram and the risk of stroke in a general population. Hypertension. 2009;53:28–34. [DOI] [PubMed] [PMC]

31.

Romhilt DW, Estes EH Jr. A point‐score system for the ECG diagnosis of left ventricular hypertrophy. Am Heart J. 1968;75:752–8. [DOI] [PubMed]

32.

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2015;16:233–70. [DOI] [PubMed]

33.

Devereux RB, Reicheck N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation. 1977;55:613–8. [DOI] [PubMed]

34.

de Marvao A, Dawes TJW, Shi W, Minas C, Keenan NG, Diamond T, et al. Population-based studies of myocardial hypertrophy: high resolution cardiovascular magnetic resonance atlases improve statistical power. J Cardiovasc Magn Res. 2014;16:16. [DOI] [PubMed] [PMC]

35.

Mehta A, Jain AC, Morise AP, Mehta MC, Billie M. Left atrial abnormality by electrocardiogram predicts left ventricular hypertrophy by echocardiography in the presence of right bundle-branch block. Clin Cardiol. 1998;21:109–14. [DOI] [PubMed] [PMC]

36.

Okin PM, Gerdts E, Wachtell K, Oikarinen L, Nieminen MS, Dahlöf B, et al. Relationship of left atrial enlargement to persistence or development of ECG left ventricular hypertrophy in hypertensive patients: implications for the development of new atrial fibrillation. J Hypertens. 2010;28:1534–40. [DOI] [PubMed]

37.

Porthan K, Kenttä T, Niiranen TJ, Nieminen MS, Oikarinen L, Viitasalo M, et al. ECG left ventricular hypertrophy as a risk predictor of sudden cardiac death. Int J Cardiol. 2019;276:125–9. [DOI] [PubMed]

38.

Cuspidi C, Grassi G. Electrocardiographic diagnosis of left-ventricular hypertrophy: good news for the clinician? J Hyperten. 2012;30:884–6. [DOI] [PubMed]

39.

Domingos H, Luzio JC, de Leles GN, Sauer L, Ovando LA. Electrocardiographic correlation in the diagnosis of left ventricular hypertrophy. Arq Bras Cardiol. 1998;71:31–5. Portuguese. [DOI] [PubMed]

40.

Schröder J, Nuding S, Müller-Werdan U, Werdan K, Kluttig A, Russ M, et al. Performance of Sokolow-Lyon index in detection of echocardiographically diagnosed left ventricular hypertrophy in a normal Eastern German population - results of the CARLA study. BMC Cardiovasc Disord. 2015;15:69. [DOI] [PubMed] [PMC]

41.

Peguero JG, Presti SL, Perez J, Issa O, Brenes JC, Tolentino A. Electrocardiographic criteria for the diagnosis of left ventricular hypertrophy. J Am Coll Cardiol. 2017;69:1694–703. [DOI] [PubMed]

42.

Afify HMA, Waits GS, Ghoneum AD, Cao X, Li Y, Soliman EZ. Peguero electrocardiographic left ventricular hypertrophy criteria and risk of mortality. Front Cardiovasc Med. 2018;5:75. [DOI] [PubMed] [PMC]

43.

Abhayaratna WP, Fatema K, Barnes ME, Seward JB, Gersh BJ, Bailey KR, et al. Left atrial reservoir function as a potent marker for first atrial fibrillation or flutter in persons ≥ 65 years of age. Am J Cardiol. 2008;101:1626–9. [DOI] [PubMed]

44.

Pelliccia F, Palmiero P, Maiello M, Losi MA, Italian Chapter of the International Society of Cardiovascular Ultrasound. Italian Chapter of the International Society of Cardiovascular Ultrasound expert consensus document on training requirements for noncardiologists using hand-carried ultrasound devices. Echocardiography. 2012;29:745–50. [DOI] [PubMed]

45.

Nagueh SF, Smiseth OA, Appleton CP, Byrd BF III, Dokainish H, Edvardsen T, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29:277–314. [DOI] [PubMed]

46.

Singh A, Addetia K, Maffessanti F, Mor-Avi V, Lang RM. LA strain categorization of LV diastolic dysfunction. JACC Cardiovasc Imaging. 2017;10:735–43. [DOI] [PubMed] [PMC]