NP physicochemical characteristics
| Variable | HSANP | S-HSANP | P |
|---|---|---|---|
| Diameter (nm)a | 308.3 ± 106.8 | 311.7 ± 109.7 | n.s. |
| Roundnessa | 0.8 ± 0.2 | 0.8 ± 0.1 | n.s. |
| Shape factora | 0.5 ± 0.1 | 0.4 ± 0.1 | n.s. |
| Hydrodynamic diameter (nm)b | |||
| Not functionalized | 104.2 ± 14.4 | 141.8 ± 4.6 | n.s. |
| Functionalized with FLAGPP1 | 296.4 ± 72.6 | 447.1 ± 131.2 | 0.028 |
| Polydispersity indexb | |||
| Not functionalized | 0.5 ± 0.1 | 0.6 ± 0.1 | n.s. |
| Functionalized with FLAGPP1 | 0.1 ± 0.1 | 0.9 ± 0.1 | 0.013 |
| ζ-Potentialb | |||
| Not functionalized | –43.7 ± 0.5 | –42.2 ± 0.3 | n.s. |
| Functionalized with FLAGPP1 | –39.5 ± 1.3 | –44.6 ± 0.8 | n.s. |
| Microencapsulation efficiency (%)c | 55.5 | 56.0 | n.s. |
| Loading efficiency (%)c | Not applicable | 22.6 | n.s. |
Values are mean ± SD. HSANP and S-HSANP, void and SGI-1027-loaded NP, respectively. a n = 60 individual NP per group; b means of technical triplicate measure; c mean from a technical duplicate measure. Kruskal-Wallis test with Bonferroni correction and multiple comparisons post hoc. n.s.: statistically not significant