Exploration of BioMat-X

Table 5.

Data referring to kinetic models

Models^※	Parameters	MUP	F1	F2	F3
Zero-order Q_t = Q₀ + k₀t	k₀	0.0026	0.0189	0.0108	0.0068
Zero-order Q_t = Q₀ + k₀t	R²	0.9480	0.9776	0.9626	0.9951
First-order ${L o g Q}_{t} = {L o g Q}_{0} + \frac{k_{1} t}{2.203}$	k₁	0.0551	0.0024	0.0042	0.0042
	R²	0.5730	0.657	0.8805	0.5359
Higuchi $\frac{M_{t}}{M_{\infty}} = k_{H} t^{1 / 2}$	k_H	0.0444	0.0169	0.0143	0.0131
	R²	0.9315	0.6359	0.5677	0.8585
	χ²	5.774	94.47	151.2	4,206
Peppas-Korsmeyer $\frac{M_{t}}{M_{\infty}} = k t^{n}$	k	0.0201	0.001	4.775 × 10^-4	7.086 × 10^-5
	n	0.7070	1.087	1.215	1.470
	R²	0.9662	0.9853	0.9622	0.9826
	χ²	2.8275	9.874	7.138	9.757
Weibull $\frac{M_{t}}{M_{\infty}} = 1 - e^{- {(\frac{t - T_{o}}{τ})}^{β}}$	T_o	8.188	8.822	10.77	8.7978
	τ	111.0	269.4	316.2	517.6
	β	1.006	1.623	1.665	1.683
	R²	0.9776	0.9984	0.9949	0.9904
	χ²	2.155	1.345	1.578	4.509

Return to article view

^※ Zero-order: Q_t represents the quantity of drug dissolved over time t, with Q₀ denoting the initial amount of drug present in the solution and k₀ is the zero-order release constant, expressed in units of concentration per time. First-order: Q_t represents the quantity of drug dissolved over time t, with Q₀ denoting the initial amount of drug present in the solution, and k₁ is the first-order rate constant. Higuchi: M_t is the amount of drug released over time t, M_∞ is the amount of drug released after time ∞, and k_H represents the Higuchi release kinetic constant. Peppas-Korsmeyer: M_t/M_∞ is the fraction of drug released at the time t, k is the release rate constant, and n is the release exponent. Weibull: M_t is the amount of drug dissolved as a function of time t, M_∞ is the total amount of drug released, T₀ accounts for the lag time measured due to the dissolution process, τ denotes a scale parameter describing the time dependence, and β describes the shape of the dissolution curve progression. MUP: mupirocin; F1: 50% sodium alginate and 50% κ-carrageenan, crosslinked; F2: 75% sodium alginate and 25% κ-carrageenan, crosslinked; F3: 25% sodium alginate and 75% κ-carrageenan, crosslinked