T cell subsets
| T cell subsets | Surface markers | Cytokine production | Gene expression of critical transcription factors |
|---|---|---|---|
| Th1/Tc1 | CXCR3 | IFN-γ | TBX21 |
| Th2/Tc2 | CCR4 | IL-4, IL-13, IL-5 | GATA3 |
| Th17/Tc17 | CCR4, CCR6 | IL-17A, IL-17F, IL-22 | RORC |
| Th17 + 1/Tc17 + 1 | CXCR3, CCR6 | IL-17A, IL-17F, IFN-γ | RORC, TBX21 |
| Th22/Tc22 | CCR4, CCR6, CCR10 | IL-22, TNF-α | AHR |
| Tfh/Tfc | CXCR5 | IL-21 | BCL6 |
| CD4+Treg/CD8+Treg | CCR2, CCR4 | IL-10, TGF-β | FOXP3 |
Tfh: T follicular helper; Tfc: T follicular cytotoxic; Treg: regulatory T; TGF: transforming growth factor