Zebrafish genes of xenobiotic metabolizing CYPs in cyp1–3 families. Drug detoxifying CYPs mentioned in the text are listed in the table. Zebrafish gene and corresponding human gene are listed in the same row. Functional conservation needs to be tested
| Gene family | Zebrafish gene | Human gene | Function |
| CYP1 | cyp1a, cyp1b1, cyp1c1,2, cyp1d1 | CYP1A1,2, CYP1B1, CYP1D1P | Catalyzing oxidative biotransformation of xenobiotics, dioxin-induced cardiovascular toxicity [14] |
| CYP2 | cyp2r1 | CYP2R1 | Microsomal vitamin D 25-hydroxylase [13] |
| - | cyp2u1 | CYP2U1 | Catalyzing ω and ω-1 hydroxylation of fatty acids [13] |
| - | cyp2n13, cyp2ps, cyp2v1, cyp2ad2,3,6 | CYP2J2 | Arachidonic acid epoxygenase [13] |
| - | cyp2ks | CYP2W1 | It is a tumor-specific CYP that oxidizes indole and chlorzoxazone, but not fatty acids [13] |
| - | cyp2y3,4 | CYP2A/B/F/S | Drug-metabolizing enzymes |
| CYP3 | cyp3a65 | CYP3A4 | Metabolism of various drugs |
| - | cyp3c1–4 | CYP3A3,4,7 | Mediates the formation of 5-hydroxydiclofenac (5-OHDF) and 6β-hydroxytestosterone [15] |
| CYP4 | cyp4f43 | CYP4F | Omega-hydroxylases of C16–C26 fatty acids [13] |
| - | cyp4v7,8 | CYP4V2 | - |
-: none