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65 results in Exploration of Digestive DiseasesSort byRelevance
Exploration of Digestive Diseases, where discovery and communication meetOpen AccessEditorialJose C. Fernandez-ChecaPublished: July 01, 2022 Explor Dig Dis. 2022;1:1–3
DOI: https://doi.org/10.37349/edd.2022.00001
Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implicationsOpen AccessReviewThe prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.Zongmei Wu ... Han MoshagePublished: July 13, 2022 Explor Dig Dis. 2022;1:4–20
DOI: https://doi.org/10.37349/edd.2022.00002
Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinomaOpen AccessReviewHepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-RuízPublished: July 29, 2022 Explor Dig Dis. 2022;1:21–39
DOI: https://doi.org/10.37349/edd.2022.00003
The hepatocyte growth factor induces an anti-inflammatory and repairing response in the cholestasis-induced colon damageOpen AccessOriginal ArticleAim: Cholestasis remains a partially characterized disease. Evidence has been gained that it is a systemic disease that begins in the liver but significantly impacts other organs and systems such [...] Read more.Jocelyn López-Ramirez ... Leticia Bucio-OrtizPublished: August 11, 2022 Explor Dig Dis. 2022;1:40–50
DOI: https://doi.org/10.37349/edd.2022.00004
Fructose, a trigger of metabolic diseases?—a narrative reviewOpen AccessReviewWorldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.Anja Baumann ... Ina BergheimPublished: August 29, 2022 Explor Dig Dis. 2022;1:51–71
DOI: https://doi.org/10.37349/edd.2022.00005
The intermicrovillar adhesion complex in gut barrier function and inflammationOpen AccessPerspectiveThe surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to b [...] Read more.Bernadette Mödl ... Robert EferlPublished: October 11, 2022 Explor Dig Dis. 2022;1:72–79
DOI: https://doi.org/10.37349/edd.2022.00006
Caspase-2 in liver disease and hepatocellular carcinomaOpen AccessReviewCaspases are key factors in the regulation of the apoptotic and/or inflammatory responses, both crucial in the pathogenesis of diverse diseases. Caspase-2 is the most evolutionary conserved albeit f [...] Read more.Amaya Lopez-Pascual ... Maite G. Fernández-BarrenaPublished: October 31, 2022 Explor Dig Dis. 2022;1:80–96
DOI: https://doi.org/10.37349/edd.2022.00007
Etiopathogenesis and pathophysiology of cholestasisOpen AccessReviewNormal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.Maitane Asensio ... Jose J. G. MarinPublished: October 31, 2022 Explor Dig Dis. 2022;1:97–117
DOI: https://doi.org/10.37349/edd.2022.00008
This article belongs to the special issue CHOLESTASIS
Probiotic human alcohol dehydrogenase-4 expressing bacteria protects from diet-induced obesity and metabolic impairment: a new concept of disease preventionOpen AccessOriginal ArticleAim: Probiotic bacteria consumption for improving human health and for disease prevention is still controversial. There is a need to develop functional probiotic bacteria with proven efficacy for [...] Read more.Rajnish Prakash Singh ... Zvi HayoukaPublished: October 31, 2022 Explor Dig Dis. 2022;1:118–136
DOI: https://doi.org/10.37349/edd.2022.00009
Cholestasis associated to inborn errors in bile acid synthesisOpen AccessReviewSeveral metabolic pathways are involved in the biotransformation of C27 neutral cholesterol to C24 primary bile acids (BAs), mainly cholic acid (CA) and chenodeoxycholic acid (CDCA), which are then conjugated with glycine or tauri [...] Read more.Ricardo Espinosa-Escudero ... Maria J. MontePublished: December 7, 2022 Explor Dig Dis. 2022;1:137–153
DOI: https://doi.org/10.37349/edd.2022.00010
This article belongs to the special issue CHOLESTASIS
The bile acid receptor TGR5 and cholestasisOpen AccessReviewMetabolic zonation in the liver carries out the maintenance of organ and body homeostasis. Hypoxia is an inherent physiological feature of the liver and contributes to the zonal properties of the he [...] Read more.Grégory Merlen ... Thierry TordjmannPublished: December 30, 2022 Explor Dig Dis. 2022;1:154–169
DOI: https://doi.org/10.37349/edd.2022.00011
This article belongs to the special issue CHOLESTASIS
Human liver stem cell-derived extracellular vesicles modulate long non-coding RNA expression profile in an in vivo model of non-alcoholic steatohepatitisOpen AccessOriginal ArticleAim: Modifications in long non-coding RNA (lncRNA) expression are associated with inflammation and fibrosis in chronic liver diseases. It has been recently demonstrated that human liver stem cell [...] Read more.Giulia Chiabotto ... Stefania BrunoPublished: August 30, 2023 Explor Dig Dis. 2023;2:172–187
DOI: https://doi.org/10.37349/edd.2023.00025
Principles of risk stratification in nonalcoholic fatty liver disease. A narrative review emphasizing non-invasive strategiesOpen AccessReviewNonalcoholic fatty liver disease (NAFLD) is an umbrella definition that describes the ectopic deposition of fat within the liver that occurs in the absence of inciting factors other than the metabol [...] Read more.Amedeo LonardoPublished: August 30, 2023 Explor Dig Dis. 2023;2:188–201
DOI: https://doi.org/10.37349/edd.2023.00026
This article belongs to the special issue Advances in Hepato-gastroenterology: Diagnosis, Prognostication, and Disease Stratification
Drug-induced cholestasis: causative agents and challenges in diagnosis and managementOpen AccessReviewDrug-induced liver injury (DILI) is an adverse reaction to drugs and other xenobiotics that can have serious consequences and jeopardise progress in pharmacological therapy. While DILI is predominan [...] Read more.Jose M. Pinazo-Bandera ... Miren García-CortésPublished: September 18, 2023 Explor Dig Dis. 2023;2:202–222
DOI: https://doi.org/10.37349/edd.2023.00027
This article belongs to the special issue CHOLESTASIS
Interplay of autophagy, apoptosis, and senescence in primary biliary cholangitisOpen AccessReviewThe pathogenesis of primary biliary cholangitis (PBC) is particularly complicated as both intrinsic and extrinsic factors are implicated. Several forms of cellular death, both programmable and non-p [...] Read more.Elias Kouroumalis ... Argyro VoumvourakiPublished: October 16, 2023 Explor Dig Dis. 2023;2:223–245
DOI: https://doi.org/10.37349/edd.2023.00028
This article belongs to the special issue CHOLESTASIS
Molecular mechanisms of metabolic disease-associated hepatic inflammation in non-alcoholic fatty liver disease and non-alcoholic steatohepatitisOpen AccessReviewNon-alcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide, with a progressive form of non-alcoholic steatohepatitis (NASH). It may progress to advanced liver diseases, [...] Read more.Chunye Zhang ... Ming YangPublished: October 25, 2023 Explor Dig Dis. 2023;2:246–275
DOI: https://doi.org/10.37349/edd.2023.00029
This article belongs to the special issue Cellular and Molecular Targets for NAFLD or MAFLD Treatments and Their Functions in Liver Fibrosis, Cirrhosis, and Cancer
Familial achalasia isolated or syndromic: about 18 familiesOpen AccessOriginal ArticleAim: Familial achalasia (FA) is a very rare condition. This work aims to evaluate its prevalence, characterize its clinical profile in a large series, and assess the efficacy and safety of pneuma [...] Read more.Amar Tebaibia ... Nadia OumniaPublished: October 26, 2023 Explor Dig Dis. 2023;2:276–281
DOI: https://doi.org/10.37349/edd.2023.00030
This article belongs to the special issue Advances in Hepato-gastroenterology: Diagnosis, Prognostication, and Disease Stratification
Diagnostic workup of suspected hereditary cholestasis in adults: a case reportOpen AccessCase ReportHereditary cholestasis comprises a broad spectrum of clinical phenotypes of varying severity. Severe forms such as progressive familial intrahepatic cholestasis (PFIC) mostly affect children with di [...] Read more.Carola Dröge ... Verena KeitelPublished: April 21, 2023 Explor Dig Dis. 2023;2:34–43
DOI: https://doi.org/10.37349/edd.2023.00016
This article belongs to the special issue CHOLESTASIS
Zebrafish as a model for drug induced liver injury: state of the art and beyondOpen AccessReviewZebrafish as a preclinical drug induced liver injury (DILI) model provides multiple advantages ranging from ease of breeding and maintenance, availability of different strains and transgenic fish am [...] Read more.Gulcin Cakan-Akdogan ... Ozlen KonuPublished: April 26, 2023 Explor Dig Dis. 2023;2:44–55
DOI: https://doi.org/10.37349/edd.2023.00017
This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directionsOpen AccessReviewThe late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) a [...] Read more.Alejandro Cueto-Sánchez ... Marina Villanueva-PazPublished: April 26, 2023 Explor Dig Dis. 2023;2:56–76
DOI: https://doi.org/10.37349/edd.2023.00018
This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application -
