Single factor analysis for the risk factors of DILF
| Variates | Severity | P value | ||||
|---|---|---|---|---|---|---|
Level ≤ 3 (n = 247; 76.7%) | Level ≥ 4 (n = 75; 23.3%) | |||||
| Gender [n (%)] | ||||||
| Male | 95 (38.5) | 31 (41.3) | 0.655 | |||
| Female | 152 (61.5) | 44 (58.7) | ||||
| Age [M (IQR)] | 54 (42–64) | 59 (50–67) | 0.515 | |||
| Clinical classification | ||||||
| Hepatocellular | 133 (53.8) | 50 (66.7) | < 0.001 | |||
| Cholestatic | 11 (4.5) | 12 (16.0) | ||||
| Mixed | 14 (5.7) | 4 (5.3) | ||||
| Abnormal liver biochemical examination | 89 (36.0) | 9 (12.0) | ||||
| Latency (days) | ||||||
| < 5 | 13 (5.3) | 2 (2.7) | 0.153 | |||
| 5–90 | 197 (79.7) | 55 (73.3) | ||||
| > 90 | 37 (15.0) | 18 (24.0) | ||||
| Comorbidities | ||||||
| Hypertension [n (%)] | Yes | 71 (28.7) | 19 (25.3) | 0.564 | ||
| No | 176 (71.3) | 56 (74.7) | ||||
| Diabetes [n (%)] | Yes | 14 (5.7) | 5 (6.7) | 0.781 | ||
| No | 233 (94.3) | 70 (93.3) | ||||
| Coronary heart disease [n (%)] | Yes | 18 (7.3) | 5 (6.7) | 0.855 | ||
| No | 129 (92.7) | 70 (93.3) | ||||
| Gallbladder lesion [n (%)] | Yes | 64 (25.9) | 47 (62.7) | < 0.001 | ||
| No | 183 (74.1) | 28 (37.3) | ||||
| Fatty liver [n (%)] | Yes | 65 (26.3) | 20 (26.7) | 0.952 | ||
| No | 182 (73.7) | 55 (73.3) | ||||
| Chronic hepatitis B [n (%)] | Yes | 12 (4.9) | 3 (4.0) | 0.757 | ||
| No | 235 (95.1) | 72 (96.0) | ||||
| Malignant tumor [n (%)] | Yes | 112 (45.3) | 10 (13.3) | < 0.001 | ||
| No | 135 (54.7) | 65 (86.7) | ||||
| ANA [n (%)] | Negative | 163 (66.0) | 28 (37.3) | < 0.001 | ||
| 1:100 | 55 (22.3) | 29 (38.7) | ||||
| ≥ 1:320 | 29 (11.7) | 18 (24.0) | ||||
| Categories of causative drugs | ||||||
| Drug categories [n (%)] | CM | 98 (59.7) | 58 (77.3) | < 0.001 | ||
| WM | 131 (53.0) | 10 (13.3) | ||||
| CM + WM | 18 (7.3) | 7 (9.3) | ||||
| Laboratory parameters of liver function (at presentation) [M (IQR)] | ||||||
| TBIL | 16.9 (8.7–53.8) | 183.6 (122.4–259.3) | < 0.001 | |||
| ALT | 240 (78–974) | 898 (330–1,452) | - | |||
| AST | 173 (53–595) | 753 (238–1,106) | - | |||
| ALP | 110 (78–169) | 174 (132–263) | - | |||
| GGT | 104 (47–250) | 193 (116–322) | < 0.001 | |||
| PT | 11.5 (10.8–12.3) | 12.6 (11.6–15.5) | < 0.001 | |||
The variables with P < 0.05 in the above univariate analysis underwent multivariate logistic regression analysis. The results showed that pre-existing gallbladder disease, clinical classification, initial TBIL, initial PT, and initial title of ANA were the independent risk factors for DILF (Table 4). M (IQR): median (interquartile range); n (%): number of cases (percentage); -: none