Percentage of cholestastic DILI in different registries reported in the literature
| Registry | Spanish DILI Registry | Latin America | DILIN Registry (USA) | India | China | Korea | Japan | Pakistan | |
|---|---|---|---|---|---|---|---|---|---|
| Type of study | Prospective | Prospective | Prospective | Prospective | Retrospective | Prospective | Prospective | Retrospective | |
| Total DILI cases | 843 | 367* | 899 | 1,288 | 1,985 | 371 | 307 | 462 | |
| Pattern of damage, n (%) | Hep | 482 (57) | 199 (62)* | 484 (53.8) | 362 (29.7) | 1,422 (71.6) | 283 (76.3) | 197 (64) | 116 (25.1) |
| Chol | 173 (21) | 123 (38)# | 210 (23.4) | 521 (42.8) | 254 (12.8) | 33 (8.9) | 48 (16) | 260 (56.2) | |
| Mix | 188 (22) | NA | 205 (22.8) | 334 (27.4) | 309 (15.6) | 55 (14.8) | 62 (20) | 86 (8.7) | |
| Main implicated agents, individually (pharmacological group) | Amoxicillin-clavulanate (Antiinfectives) | Amoxicillin-clavulate (NA) | Amoxicillin-clavulanate (Antiinfectives) | Antituberculous (Antiinfectives) | Azithromycin (Antibiotics) Gu-kang capsule (Chinese traditional patent medicine) | NA (Herbal medications) | NA (Anti-inflammatory drugs) | Antituberculous (Antiinfectives) | |
| HILI cases, n (%) | 32 (4) | 29 (8) | 85 (10) | 179 (13.9) | 563 (28) | 270 (73) | 27 (8.7) | 42 (9) | |
| References | [3] | [4, 5] | [6] | [7] | [8] | [9] | [10] | [11] | |
* 322 patients were cases due to conventional medicines, 29 by herbs and 16 by anabolic androgenic steroids (AAS); # percentage of cholestatic and mixed DILI cases together. Percentage of pattern of damage only includes results of conventional medicines. Chol: cholestatic; DILIN: Drug-Induced Liver Injury Network; Hep: hepatocellular; HILI: herbal and dietary supplements-induced liver injury; Mix: mixed; NA: not available