Most representative drugs in different cholestatic phenotypes of liver damage
| Acute cholestasis | Chronic cholestasis | |||||
|---|---|---|---|---|---|---|
| Bland cholestasis | Cholestatic hepatitis | Autoimmune features | Vanishing bile duct syndrome | Secondary sclerosing cholestasis | Autoimmune features | Fibrosis/cirrhosis |
AAS Herbs (tribulus) Warfarin Thiabendazole Oral contraceptives SARS-CoV-2 vaccines | NSAIDs Antiinfectives (amoxicillin-clavulanate, penicillins, macrolides, TMP-SMX, etc.) Statins Tricyclic antidepressants Selective serotonin reuptake inhibitors Azathioprine Eculizumab Cisplatin Herbs (Kratom, Ashwagandha) | Statins (atorvastatin) Nitrofurantoin SARS-CoV-2 vaccines | Antibiotics (amoxicillin/clavulanate, azithromycin, flucloxacillin, quinolones, etc.) NSAIDs (ibuprofen, diclofenac) Psychotropes (chlorpromazine, imipramine, carbamazepine, etc.) | Immunotherapy (nivolumab, pembrolizumab, durvalumab, etc.) Docetaxel Ketamine Atorvastatin | Nitrofurantoin | Chlorpromazine Nitrofurantoin |