Genetic factors related to cholestasis-induced by xenobiotics
| Association | HLA type | References |
|---|---|---|
General association with cholestatic/mixed DILI (High positive predictive value) | DRB1*15 DQB1*06 | [115] |
| A*33:01¥ | [65] | |
Association with specific agents (High positive predictive value) | ||
Terbinafine Fenofibrate Ticlopidine | A*33:01 | [65, 118] |
| Amoxicillin-clavulanate | A*0201 B1*1501 B*1801 DQB1*02 DQB1*0602 DQR1*06 DRB1*07 DRB1*15 DRB5*0101 | [119] |
| Flucoxacillin | B*5101 B*57-03 | [12, 115] |
| Oral contraceptives | ABCB11 1331T>C polymorphism | [22] |
¥ Excluding cases of amoxicillin-clavulanate and flucoxacillin