List of potential mitochondrial biomarkers involved in liver metastases by MPM invasive cells
| Gene | Full name | Change # |
|---|---|---|
| Slc25a5 | ADP/ATP translocase 2 | ↓ |
| Prdx5 | Peroxiredoxin-5, mitochondrial | ↓ |
| Acadm | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | ↓ |
| Acads | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | ↓ |
| Hmgcs2 | Hydroxymethylglutaryl-CoA synthase, mitochondrial | ↓ |
| Idh3a | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | ↓ |
| Dlat | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | ↓ |
| Cpox | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial | ↓ |
| Ndufa10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | ↓ |
| Aldh5a1 | Succinate-semialdehyde dehydrogenase, mitochondrial | ↓ |
| Fis1 | Mitochondrial fission 1 protein | ↓ |
| Sardh | Sarcosine dehydrogenase, mitochondrial | ↓ |
| Nln | Neurolysin, mitochondrial | ↓ |
| Acadl | Long-chain specific acyl-CoA dehydrogenase, mitochondrial | ↑ |
| Aco2 | Aconitate hydratase, mitochondrial | ↑ |
| Hadha | Trifunctional enzyme subunit alpha, mitochondrial | ↑ |
| Grpel1 | GrpE protein homolog 1, mitochondrial | ↑ |
| Micu1 | Calcium uptake protein 1, mitochondrial | ↑ |
| Uqcrq | Cytochrome b-c1 complex subunit 8 | ↑ |
| Vdac2 | Voltage-dependent anion-selective channel protein 2 | ↑ |
| Ogdh | 2-oxoglutarate dehydrogenase, mitochondrial | ↑ |
| Phb | Prohibitin | ↑ |
| Mgst1* | Microsomal glutathione S-transferase 1 | ↑ |
| Decr1* | 2,4-dienoyl-CoA reductase 1 | ↓ |
| Prdx3* | Thioredoxin-dependent peroxide reductase, mitochondrial | ↓ |
* Proteins not strictly located in the mitochondria (according to https://www.proteinatlas.org/). Gene names are given for Rattus norvegicus (according to https://www.uniprot.org/). #: significant changes (P < 0.05) in G2 vs. G1, and G3 vs. G2. ↑: increase; ↓: decrease
Note. Adapted from “Curcumin treatment identifies therapeutic targets within biomarkers of liver colonization by highly invasive mesothelioma cells—potential links with sarcomas,” by Pouliquen DL, Boissard A, Henry C, Blandin S, Richomme P, Coqueret O, et al. Cancers (Basel). 2020;12:3384 (https://www.mdpi.com/2072-6694/12/11/3384). CC BY.