miRNA targeting TJ protein expression in HCC
| S.No | miRNA | Target TJ protein | Role in HCC | HCC severity | Reference |
|---|---|---|---|---|---|
| 1 | miR-99b | ↓ CLDN11 | Migration and metastasis of HCC | Promotes HCC progression | [72] |
| 2 | miR-191-5p | ↑ ZO-1 | Decreased cellular invasiveness | Inhibits HCC progression | [73] |
| 3 | miR-122 | ↑ E-cadherin, ZO-1 and α-catenin | Increased cell adhesion, and cytoskeleton depolymerization in HCC | Inhibits HCC progression | [74] |
| 4 | miR-103 | ↓VE-Cad, p120-catenin (p120) and ZO-1 | Enhances the transendothelial incursion of tumor cells | Promotes HCC progression | [75] |
| 5 | miR- 638, miR-663a, miR-3648, and miR-4258 | ↓ VE-Cad and ZO-1 | Increased rates of hepatic and pulmonary metastasis and endothelial junction integrity loss favours the metastatic cancer cells | Promotes HCC progression and metastasis | [76] |
| 6 | miR-23a-3p | ↓ TJP-1, OCLN, and CLDN5 | HCC cell migration, incursion and vascular permeability | Promotes HCC progression | [77] |
VE-Cad: vascular endothelial cadherin; TJP-1: TJ protein 1; ↑: resembles upregulation; ↓: resembles downregulation