Exploration of Digestive Diseases

Table 2. Performance of HCC risk scores in patients with chronic hepatitis B after hepatitis B surface antigen seroclearance in Yang et al. study [50, 57–60]

Parameters	Novel score	CU-HCC score	REACH-B score	PAGE-B score	mPAGE-B score
Age (years)	< 40 = 0 40–49 = + 1 50–59 = + 2 ≥ 60 = + 3	≤ 50 = 0 > 50 = + 3	+ 1 for every 5 years from 35 to 65 years old	16–29 = 0 30–39 = + 2 40–49 = + 4 50–59 = + 6 60–69 = + 8 ≥ 70 = + 10	< 30 = 0 30–39 = + 3 40–49 = + 5 50–59 = + 7 60–69 = + 9 ≥ 70 = + 11
Gender			Male = + 2 Female = 0	Male = + 6 Female = 0	Male = + 2 Female = 0
Cirrhosis	Yes = + 2 No = 0	Yes = + 15 No = 0
Family history of HCC	Yes = + 1 No = 0
More-than-moderate drinking	Yes = + 2 No = 0
Albumin (g/L)		≤ 35 = + 20 > 35 = 0			< 30 = + 3 30–34 = + 2 35–39 = + 1 ≥ 40 = 0
Total bilirubin (µmol/L)		> 18 = + 1.5 ≤ 18 = 0
ALT (IU/L)			≥ 45 = + 2 15–44 = + 1 < 15 = 0
HBV DNA (log copies/mL)		≤ 4 = 0 4–6 = + 1 > 6 = + 4	≥ 6 = + 4 5–6 = + 5 4–5 = + 3 < 4 = 0
HBeAg status			Positive = + 2 Negative = 0
Platelet (× 10⁹/L)				< 100 = + 9 100–200 = + 6 ≥ 200 = 0	< 100 = + 5 100–149 = + 4 150–199 = + 3 200–249 = + 2 ≥ 250 = 0
Discriminatory performance by time-dependent AUROC (95% CI)
Prediction for HCC in 5 years	0.799 (0.722–0.877)	0.739 (0.656–0.822)	0.704 (0.627–0.781)	0.657 (0.564–0.745)	0.732 (0.642–0.823)
Prediction for HCC in 10 years	0.835 (0.751–0.919)	0.763 (0.682–0.844)	0.734 (0.653–0.814)	0.705 (0.608–0.802)	0.790 (0.714–0.867)

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ALT: alanine aminotransferase; AUROC: area under the receiver operating characteristic curve; CI: confidence interval; HBeAg: hepatitis B e antigen; HBV: hepatitis B virus; HCC: hepatocellular carcinoma

Declarations

Author contributions

JCTL and VWKH: Writing—original draft, Writing—review & editing. GLHW, VWSW, and TCFY: Conceptualization, Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

JCTL and VWKH declare that they have no conflicts of interest. GLHW has served as an advisory committee member for AstraZeneca, Gilead Sciences, and Janssen, and as a speaker for Abbott, AbbVie, Ascletis, Bristol-Myers Squibb, Echosens, Gilead Sciences, Janssen, and Roche. She has also received a research grant from Gilead Sciences. VWSW has served as a consultant or advisory committee member for AbbVie, Boehringer Ingelheim, Echosens, Intercept, Inventiva, Novo Nordisk, Pfizer, and TARGET PharmaSolutions; and a speaker for Abbott, AbbVie, Gilead Sciences, and Novo Nordisk. He has received a research grant from Gilead Sciences, and is a cofounder of Illuminatio Medical Technology Limited. TCFY has served as an advisory committee member and a speaker for Gilead Sciences.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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