Exploration of Digestive Diseases

Table 1

Hemodynamic definitions of pulmonary hypertension

Definition	Hemodynamic criteria	Clinical groups
PH	mPAP > 20 mmHg
Pre-capillary PH	mPAP > 20 mmHg PAWP ≤ 15 mmHg PVR > 2 WU	Group 1: PAH: idiopathic, heritable, associated with drugs/toxins, with concomitant diseases (including portal hypertension), with features of venous/capillary involvement Group 3: PH associated with lung diseases and/or hypoxia Group 4: PH due to pulmonary artery obstructions Group 5: PH with unclear and/or multifactorial mechanisms
Isolated post-capillary PH	mPAP > 20 mmHg PAWP > 15 mmHg PVR ≤ 2 WU	Group 2: PH associated with left heart disease Group 5: PH with unclear and/or multifactorial mechanisms
Combined pre- and post-capillary PH	mPAP > 20 mmHg PAWP > 15 mmHg PVR > 2 WU

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Portopulmonary hypertension belongs to PAH (group 1 PH) characterized by precapillary PH in the absence of other causes of pre-capillary PH, such as chronic thrombo-embolic PH and PH associated with lung diseases. More details are reported in Humbert M, et al. Eur Heart J 2022 [20]. mPAP: mean pulmonary arterial pressure; PAH: pulmonary arterial hypertension; PAWP: pulmonary arterial wedge pressure; PH: pulmonary hypertension; PVR: pulmonary vascular resistance; WU: Wood units (1 WU = 80 dyn.s.cm^-5)

Note. Adapted with permission from “Portopulmonary hypertension: An unfolding story” by Thévenot T, Savale L, Sitbon O. Clin Res Hepatol Gastroenterol. 2020;45:101492 (https://www.sciencedirect.com/science/article/abs/pii/S221074012030187X?via%3Dihub). © 2020 Elsevier Masson SAS.